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. 2018 May 16:2018:8928706.
doi: 10.1155/2018/8928706. eCollection 2018.

Myxoid Liposarcoma: Prognostic Factors and Metastatic Pattern in a Series of 148 Patients Treated at a Single Institution

Francesco Muratori  1 , Leonardo Bettini  1 , Filippo Frenos  1 , Nicola Mondanelli  1 , Daniela Greto  2 , Lorenzo Livi  2 , Alessandro Franchi  3 , Giuliana Roselli  4 , Maurizio Scorianz  1 , Rodolfo Capanna  3 , Domenico Campanacci  1
Affiliations

Myxoid Liposarcoma: Prognostic Factors and Metastatic Pattern in a Series of 148 Patients Treated at a Single Institution

Francesco Muratori et al. Int J Surg Oncol. .

Abstract

Objectives: The authors reported a retrospective study on myxoid liposarcomas (MLs), evaluating factors that may influence overall survival (OS), local recurrence-free survival (LRFS), metastasis-free survival (MFS), and analyzing the metastatic pattern.

Methods: 148 MLs were analyzed. The sites of metastases were investigated.

Results: Margins (p = 0.002), grading (p = 0,0479), and metastasis (p < 0,0001) were significant risk factors affecting overall survival (OS). Type of presentation (p = 0.0243), grading (p = 0,0055), margin (p = 0.0001), and local recurrence (0.0437) were risk factors on metastasis-free survival (MFS). Authors did not observe statistically significant risk factors for local recurrence-free survival (LRFS) and reported 55% extrapulmonary metastases and 45% pulmonary metastases.

Conclusion: Margins, grading, presentation, local recurrence, and metastasis were prognostic factors. Extrapulmonary metastases were more frequent in myxoid liposarcoma.

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Figures

Figure 1
Figure 1
Margins represent a significant risk factor (p = 0,002) in overall survival (OS).
Figure 2
Figure 2
Grading is a significant risk factor (p = 0,0479) in overall survival (OS).
Figure 3
Figure 3
Metastasis is a high significant risk factor (p < 0,0001) in overall survival (OS).
Figure 4
Figure 4
Grading is a significant risk factor (p = 0,0055) in metastasis-free survival (MFS).
Figure 5
Figure 5
Local recurrence is a significant risk factor (p = 0,0437) in metastasis-free survival (MFS).
Figure 6
Figure 6
Presentation is a significant risk factor (p = 0,0243) in metastasis-free survival (MFS).
See this image and copyright information in PMC

References

    1. Fritchie K. J., Goldblum J. R., Tubbs R. R., et al. The expanded histologic spectrum of myxoid liposarcoma with an emphasis on newly described patterns: Implications for diagnosis on small biopsy specimens. American Journal of Clinical Pathology. 2012;137(2):229–239. doi: 10.1309/AJCP90YNOKBAGCDM. - DOI - PubMed
    1. Fletcher C. D., Hogendoorn P., Mertens F. WHO Classification of Tumours of Soft Tissue and Bone. 4th. Lyon, France: IARC Press; 2013.
    1. Lewis J. J., Leung D., Woodruff J. M., Brennan M. F. Retroperitoneal soft-tissue sarcoma: Analysis of 500 patients treated and followed at a single institution. Annals of Surgery. 1998;228(3):355–365. doi: 10.1097/00000658-199809000-00008. - DOI - PMC - PubMed
    1. Linehan D. C., Lewis J. J., Leung D., Brennan M. F. Influence of Biologic Factors and Anatomic Site in Completely Resected Liposarcoma. Journal of Clinical Oncology. 2000;18(8):1637–1643. doi: 10.1200/JCO.2000.18.8.1637. - DOI - PubMed
    1. McCormick D., Mentzel T., Beham A., Fletcher C. D. M. Dedifferentiated liposarcoma: clinicopathologic analysis of 32 cases suggesting a better prognostic subgroup among pleomorphic sarcomas. The American Journal of Surgical Pathology. 1994;18(12):1213–1223. doi: 10.1097/00000478-199412000-00004. - DOI - PubMed

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