Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Dec 6;61(2):135-143.
doi: 10.1515/jvetres-2017-0017. eCollection 2017 Jun.

Roles of African Swine Fever Virus Structural Proteins in Viral Infection

Ning Jia  1 , Yunwen Ou  1   2 , Zygmunt Pejsak  3 , Yongguang Zhang  2 , Jie Zhang  2
Affiliations

Roles of African Swine Fever Virus Structural Proteins in Viral Infection

Ning Jia et al. J Vet Res. .

Abstract

African swine fever virus (ASFV) is a large, double-stranded DNA virus and the sole member of the Asfarviridae family. ASFV infects domestic pigs, wild boars, warthogs, and bush pigs, as well as soft ticks (Ornithodoros erraticus), which likely act as a vector. The major target is swine monocyte-macrophage cells. The virus can cause high fever, haemorrhagic lesions, cyanosis, anorexia, and even fatalities in domestic pigs. Currently, there is no vaccine and effective disease control strategies against its spread are culling infected pigs and maintaining high biosecurity standards. African swine fever (ASF) spread to Europe from Africa in the middle of the 20th century, and later also to South America and the Caribbean. Since then, ASF has spread more widely and thus is still a great challenge for swine breeding. The genome of ASFV ranges in length from about 170 to 193 kbp depending on the isolate and contains between 150 and 167 open reading frames (ORFs). The ASFV genome encodes 150 to 200 proteins, around 50 of them structural. The roles of virus structural proteins in viral infection have been described. These proteins, such as pp220, pp62, p72, p54, p30, and CD2v, serve as the major component of virus particles and have roles in attachment, entry, and replication. All studies on ASFV proteins lay a good foundation upon which to clarify the infection mechanism and develop vaccines and diagnosis methods. In this paper, the roles of ASFV structural proteins in viral infection are reviewed.

Keywords: African swine fever virus; review; structural proteins; viral infection.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interests Statement: The authors declare that there is no conflict of interests regarding the publication of this article.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Cisek A.A., Dąbrowska I., Gregorczyk K.P., Wyżewski Z.. African Swine Fever Virus: a new old enemy of Europe. Ann Parasitol. 2016;62:161–167. - PubMed
    1. Alfonso P., Quetglas J.I., Escribano J.M., Alonso C.. Protein PE120R of African swine fever virus is post-translationally acetylated as revealed by post-source decay MALDI mass spectrometry. Virus Gen. 2007;35:81–85. - PubMed
    1. Alonso C., Miskin J., Hernáez B., Fernandez-Zapatero P., Soto L., Cantó C., Rodríguez-Crespo I., Dixon L., Escribano J.M.. African swine fever virus protein p54 interacts with the microtubular motor complex through direct binding to light-chain dynein. J Virol. 2001;75:9819–9827. - PMC - PubMed
    1. Andrés G., Alejo A., Salas J., Salas M.L.. African swine fever virus polyproteins pp220 and pp62 assemble into the core shell. J Virol. 2002;76:12473–12482. - PMC - PubMed
    1. Andrés G., García-Escudero R., Viñuela E., Salas M.L., Rodríguez J.M.. African swine fever virus structural protein pE120R is essential for virus transport from assembly sites to plasma membrane but not for infectivity. J Virol. 2001;75:6758–6768. - PMC - PubMed