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. 1985 Nov 15;230(4727):810-3.
doi: 10.1126/science.2997921.

A new HTLV-III/LAV encoded antigen detected by antibodies from AIDS patients

J S Allan, J E Coligan, T H Lee, M F McLane, P J Kanki, J E Groopman, M Essex

A new HTLV-III/LAV encoded antigen detected by antibodies from AIDS patients

J S Allan et al. Science. .

Abstract

A newly identified protein from HTLV-III/LAV, the virus implicated as the etiologic agent of the acquired immune deficiency syndrome, was studied. This protein, which has a molecular weight of 27,000 (p27), was shown by amino acid sequencing to have a coding origin 3' to the env gene on the HTLV-III genome. The presence of antibodies to p27 in virus-exposed individuals indicated that this gene is functional in the natural host.

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