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Review
. 2018 Nov;102(11):1824-1836.
doi: 10.1097/TP.0000000000002326.

Donor-derived Viral Infections in Liver Transplantation

Hannah Nam  1 , Kathy M Nilles  2 , Josh Levitsky  3   4 , Michael G Ison  1   4
Affiliations
Review

Donor-derived Viral Infections in Liver Transplantation

Hannah Nam et al. Transplantation. 2018 Nov.

Abstract

Donor-derived infections are defined as any infection present in the donor that is transmitted to 1 or more recipients. Donor-derived infections can be categorized into 2 groups: "expected" and "unexpected" infections. Expected transmissions occur when the donor is known to have an infection, such as positive serology for cytomegalovirus, Epstein Barr virus, or hepatitis B core antibody, at the time of donation. Unexpected transmissions occur when a donor has no known infection before donation, but 1 or more transplant recipients develop an infection derived from the common donor. Unexpected infections are estimated to occur in far less than 1% of solid organ transplant recipients. We will review the epidemiology, risk factors, and approaches to prevention and management of donor-derived viral infectious disease transmission in liver transplantation.

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Figures

FIGURE 1.
FIGURE 1.
Timing of positive screening testing after infection of the donor.
FIGURE 2.
FIGURE 2.
Approach to a potential donor-derived infection.
See this image and copyright information in PMC

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