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Comparative Study
. 2018 Nov:202:311-314.e2.
doi: 10.1016/j.jpeds.2018.06.008. Epub 2018 Jul 3.

T-Cell Receptor Excision Circles in HIV-Exposed, Uninfected Newborns Measured During a National Newborn Screening Program for Severe Combined Immunodeficiency

Josiane Warszawski  1 , Caroline Thomas  2 , Olivia Dialla  3 , Valérie Garrait  4 , Catherine Dollfus  5 , Veronique Reliquet  6 , Laure Clech  7 , Cécile Dert  8 , Laurent Mandelbrot  9 , Marie Audrain  10 , Stéphane Blanche  11 ; ANRS EPF Study Group
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Comparative Study

T-Cell Receptor Excision Circles in HIV-Exposed, Uninfected Newborns Measured During a National Newborn Screening Program for Severe Combined Immunodeficiency

Josiane Warszawski et al. J Pediatr. 2018 Nov.

Abstract

Severe combined immunodeficiency screening by measuring T-receptor excision circles at birth allows evaluation of the impact of various maternal conditions on newborn immunity. The slight decrease observed in a French cohort of newborns to HIV-infected mothers can be explained by the confounding factors of prematurity and African descent.

Keywords: HIV; T cell; TREC; lymphocyte; newborn; pregnancy.

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