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. 2018 Jul 5;8(7):e020303.
doi: 10.1136/bmjopen-2017-020303.

Cardiovascular mortality in a Western Asian country: results from the Iran Cohort Consortium

Noushin Fahimfar  1 , Davood Khalili  2   3 , Sadaf Ghajarieh Sepanlou  4 , Reza Malekzadeh  4   5 , Fereidoun Azizi  2 , Mohammad Ali Mansournia  1 , Hamidreza Roohafza  6 , Mohammad Hassan Emamian  7 , Farzad Hadaegh  2 , Hossein Poustchi  4 , Marjan Mansourian  6   8 , Hassan Hashemi  9 , Maryam Sharafkhah  1   4 , Akram Pourshams  4 , Farshad Farzadfar  10 , Ewout W Steyerberg  11   12 , Akbar Fotouhi  1
Affiliations

Cardiovascular mortality in a Western Asian country: results from the Iran Cohort Consortium

Noushin Fahimfar et al. BMJ Open. .

Abstract

Objectives: Cardiovascular mortality in Western Asia is high and still rising. However, most data documented on risk prediction has been derived from Western countries and few population-based cohort studies have been conducted in this region. The current study aimed to present the process of pooling data and cardiovascular disease (CVD) mortality incidences for four Iranian cohorts.

Methods: From the Iran Cohort Consortium, the Golestan Cohort Study (GCS), Tehran Lipid and Glucose Study, Isfahan Cohort Study (ICS) and the Shahroud Eye Cohort Study (ShECS) were eligible for the current study since they had appropriate data and follow-up visits. Age-standardised CVD mortality rates were estimated for ages 40-80 and 40-65 years. Cox regression was used to compare mortalities among cohorts. Adjusted marginal rates were calculated using Poisson regression.

Results: Overall, 61 291 participants (34 880 women) aged 40-80 years, free of CVD at baseline, were included. During 504 606 person-years of follow-up, 1981 CVD deaths (885 women) occurred. Age-standardised/sex-standardised premature CVD mortality rates were estimated from 133 per 100 000 person-years (95% CI 81 to 184) in ShECS to 366 (95% CI 342 to 389) in the GCS. Compared with urban women, rural women had higher CVD mortality in the GCS but not in the ICS. The GCS population had a higher risk of CVD mortality, compared with the others, adjusted for conventional CVD risk factors.

Conclusions: The incidence of CVD mortality is high with some differences between urban and rural cohorts in Iran as a Western Asian country. Pooling data facilitates the opportunity to globally evaluate risk prediction models.

Keywords: cardiovascular diseases; cohort studies; epidemiology of cardiovascular diseases; mortality.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Adjusted CVD mortality rates across cohorts, location of residence and genders. CVD, cardiovascular disease; GCS, Golestan Cohort Study (phase 1); ICS, Isfahan Cohort Study; ShECS, Shahroud Eye Cohort Study; TLGS, Tehran Lipid and Glucose Study. Adjustment was for age, sex, hypertension, smoking, self-reported diabetes and body mass index.
See this image and copyright information in PMC

References

    1. Organization WH. The top 10 causes of death. 2018. http://www.who.int/mediacentre/factsheets/fs317/en/
    1. World Health Organization. WHO-Non communicable diseases (NCD) Country Profiles. 2014. http://www.who.int/nmh/countries/2011/en/
    1. Farzadfar F, Danaei G, Namdaritabar H, et al. National and subnational mortality effects of metabolic risk factors and smoking in Iran: a comparative risk assessment. Popul Health Metr 2011;9:55 10.1186/1478-7954-9-55 - DOI - PMC - PubMed
    1. Esteghamati A, Etemad K, Koohpayehzadeh J, et al. Trends in the prevalence of diabetes and impaired fasting glucose in association with obesity in Iran: 2005-2011. Diabetes Res Clin Pract 2014;103:319–27. 10.1016/j.diabres.2013.12.034 - DOI - PubMed
    1. World Health Organization. Prevention of cardiovascular disease: guidelines for assessment and management of total cardiovascular risk. Geneva, Switzerland, 2007. http://www.who.int/cardiovascular_diseases/guidelines/PocketGL.ENGLISH.A...

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