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. 1985 Nov;147(1):217-22.
doi: 10.1016/0042-6822(85)90243-0.

Human cytomegalovirus completely helps adeno-associated virus replication

R A McPherson, L J Rosenthal, J A Rose

Human cytomegalovirus completely helps adeno-associated virus replication

R A McPherson et al. Virology. 1985 Nov.

Abstract

Coinfection of adeno-associated virus (AAV) with human cytomegalovirus (HCMV) strain Towne in human embryonic fibroblasts resulted in accumulation of AAV capsid antigen and production of infectious AAV with a lag of 24 hr compared to AAV replication in AAV-adenovirus coinfections. In contrast to previous observation, these findings demonstrated that HCMV is a competent helper virus for the complete replication of AAV. In addition, HCMV and AAV were synergistic in their cytopathic effects on cells, suggesting the possibility that AAV may play a role in the pathogenicity of HCMV infections.

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