Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2018 Aug;28(8):785-786.
doi: 10.1038/s41422-018-0064-0.

Competing for enhancers: PVT1 fine-tunes MYC expression

Abhijit Parolia  1   2   3 , Marcin Cieślik  1   2 , Arul M Chinnaiyan  4   5   6   7   8
Affiliations
Comment

Competing for enhancers: PVT1 fine-tunes MYC expression

Abhijit Parolia et al. Cell Res. 2018 Aug.
No abstract available

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
PVT1 promoter represses MYC transcription in cis. Top: In normal topology, a number of PVT1 intragenic enhancer elements preferentially interact with the PVT1 gene promoter and sustain expression of the non-coding transcript. Bottom: In malignant topology, caused by mutational, structural or epigenetic inactivation of the PVT1 promoter, intragenic enhancer elements instead interact with the adjacent MYC oncogene. This increases MYC expression imparting proliferative advantage to cancer cells
See this image and copyright information in PMC

Comment on

  • Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element.
    Cho SW, Xu J, Sun R, Mumbach MR, Carter AC, Chen YG, Yost KE, Kim J, He J, Nevins SA, Chin SF, Caldas C, Liu SJ, Horlbeck MA, Lim DA, Weissman JS, Curtis C, Chang HY. Cho SW, et al. Cell. 2018 May 31;173(6):1398-1412.e22. doi: 10.1016/j.cell.2018.03.068. Epub 2018 May 3. Cell. 2018. PMID: 29731168 Free PMC article.

References

    1. Dixon JR, Gorkin DU, Ren B. Mol. Cell. 2016;62:668–680. doi: 10.1016/j.molcel.2016.05.018. - DOI - PMC - PubMed
    1. Cho SW, et al. Cell. 2018;173:1398–1412. doi: 10.1016/j.cell.2018.03.068. - DOI - PMC - PubMed
    1. Marchese FP, Huarte M. Cell. 2018;173:1318–1319. doi: 10.1016/j.cell.2018.05.023. - DOI - PubMed
    1. Huppi K, Pitt JJ, Wahlberg BM, Caplen N. J. Front. Genet. 2012;3:69. - PMC - PubMed
    1. Sotelo, J. et al. Proc. Natl Acad. Sci. USA107, 3001–3005 (2010).

LinkOut - more resources