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Review
. 2018 Sep;53(9):989-998.
doi: 10.1007/s00535-018-1479-6. Epub 2018 Jul 6.

The state of the art on treatment of Crohn's disease

Hai Yun Shi  1   2 , Siew Chien Ng  3
Affiliations
Review

The state of the art on treatment of Crohn's disease

Hai Yun Shi et al. J Gastroenterol. 2018 Sep.

Abstract

Crohn's disease (CD) is a chronic, progressive, and destructive disease of the gastrointestinal tract. Although its incidence appears to be stable or decreasing in most countries in the North America and Europe, the incidence is rising rapidly in Asian countries. Immunomodulators and biologics are increasingly used to avoid long-term bowel damage and subsequent disability. Therapeutic drug monitoring facilitates optimizing thiopurines and anti-TNFs use. New biologic agents targeting various pathological pathways of CD are blooming in recent years, and the high cost of biologics and expiration of patents for several biologic agents have driven the utility of biosimilars for CD treatment. Here, the literature regarding the efficacy, safety, and withdrawal of the drugs, as well as the evolution of therapeutic targets will be reviewed.

Keywords: Biologics; Crohn’s disease; Mucosal healing; Target.

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Conflict of interest statement

The authors declare that they have no competing interests.

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