Efficient CO2 removal using extracorporeal lung and renal assist device

Abstract

We developed a novel system comprising acid infusion, membrane lung, and a continuous renal replacement therapy console for efficient CO₂ removal at a low blood flow. To evaluate the new system, we used an ex vivo experimental model using swine blood. A liter of aliquoted blood adjusted to pH 7.25 and pCO₂ 65 mm Hg was mixed with acid (0, 10, or 20 mL of lactic or hydrochloric acid [1 mol/L]) and was immediately delivered to the system in a single pass. We collected blood samples at each point of the circuit and calculated the amount of CO₂ eliminated by the membrane lung. The new system removed 13.2 ± 0.8, 32.0 ± 2.1, and 51.6 ± 3.7 mL/min of CO₂ (with 0, 10, and 20 mEq/L of lactic acid) and 21.2 ± 1.2, 27.3 ± 0.3, and 42.0 ± 1.3 mL/min (with 0, 10, and 20 mEq/L of hydrochloric acid), respectively. The levels of lactate and Cl^- ions for acid-base equilibrium were restored after continuous hemodiafiltration. Thus, the amount of CO₂ eliminated by the membrane lung was 3.9 times higher with lactic acid and 2.0 times higher with hydrochloric acid compared with non-acid controls. In conclusion, this easy-to-setup CO₂ removal system was safe, effective, and removed CO₂ at a low blood flow.

Keywords: Acid infusion; Artificial lung; ECCO2R; Lung injury; Renal replacement therapy.