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Case Reports
. 2018 Oct;48(10):1764-1767.
doi: 10.1002/eji.201847645. Epub 2018 Jul 19.

Trousseau's syndrome triggered by an immune checkpoint blockade in a non-small cell lung cancer patient

Yuko Horio  1 , Koutaro Takamatsu  2 , Daisuke Tamanoi  1 , Ryo Sato  1 , Koichi Saruwatari  1 , Tokunori Ikeda  2   3 , Shunya Nakane  2   4 , Makoto Nakajima  2 , Sho Saeki  1 , Hidenori Ichiyasu  1 , Kazuhiko Fujii  1 , Yusuke Tomita  1
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Free article
Case Reports

Trousseau's syndrome triggered by an immune checkpoint blockade in a non-small cell lung cancer patient

Yuko Horio et al. Eur J Immunol. 2018 Oct.
Free article

Abstract

PD-1 blockade therapy activates T cells by blocking the interaction between PD-1 and PD-L1 and promotes IFN-γ and Th1 cytokine production. In turn, IFN-γ and Th1 cytokines produced by activated T cells promote TF synthesis in monocytes/macrophages, which results in hypercoagulability leading to thrombosis.

Keywords: Immune checkpoint blockade; Immune-related adverse event; Lung cancer; Tissue factor; Trousseau's syndrome.

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