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. 2018 Jul 2;218(3):388-397.
doi: 10.1093/infdis/jiy160.

Prevalence and Epidemiologic Profile of Oral Infection with Alpha, Beta, and Gamma Papillomaviruses in an Asian Chinese Population

Martin C S Wong  1 , Alexander C Vlantis  2 , Miaoyin Liang  1 , Po Yee Wong  3 , Wendy C S Ho  3 , Siaw S Boon  3 , Ryan Kin Ho Sze  3 , Colette Leung  1 , Paul K S Chan  3   4 , Zigui Chen  3   4
Affiliations

Prevalence and Epidemiologic Profile of Oral Infection with Alpha, Beta, and Gamma Papillomaviruses in an Asian Chinese Population

Martin C S Wong et al. J Infect Dis. .

Abstract

Background: Knowledge of the prevalence of and risk factors for oral human papillomavirus (HPV) infection, especially cutaneous types, is limited.

Methods: A population-based study using next-generation sequencing consecutively recruited asymptomatic individuals aged 18-64 years from a proportional sampling of the general population of Hong Kong, according to age groups, gender, and regions of residence. We examined associations of alpha-, beta-, and gamma-HPVs from oral rinse samples with participants' sociodemographics by logistic regression models.

Results: The prevalence of oral HPV infection among 1426 ethnic Chinese was 15.5% (95% confidence interval [CI], 13.7%-17.5%), 2.5% (95% CI, 1.8%-3.5%), 11.9% (95% CI, 10.3%-13.6%), and 2.9% (95% CI, 2.1%-3.9%) for any type, alpha-, beta-, and gamma-HPV, respectively. Prevalence of any high-risk HPV was 0.8% (95% CI, 0.4%-1.4%), and that of HPV-16 was 0.4% (95% CI, 0.2%-0.8%). HPV-8 and HPV-98 were the most common beta types detected, while HPV-4 and HPV-SD2R were the most common gamma types. Prevalence of alpha- and beta/gamma-HPV infection showed a similar pattern of increase with age, and was higher in men than women. Smoking, drinking, oral sex, and more sexual partners were associated with alpha-HPV. Teeth brushing before sleep was protective for beta/gamma-HPVs.

Discussion: The epidemiologic factors associated with oral infection with alpha-HPVs are different from those of beta/gamma-HPVs, suggesting different modes of acquisition and persistence.

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Figures

Figure 1.
Figure 1.
Age- and sex-specific prevalence of oral alpha-, beta-, and gamma human papillomavirus infections.
Figure 2.
Figure 2.
Distribution of human papillomavirus (HPV) types in oral rinse samples. The tree was inferred from the topology based on the complete genome alignment. The barplot on the right panel of the tree shows the number of samples positive for each type. Samples with coinfections were counted more than once. High-risk (HR) alpha-HPV, red; low-risk (LR) alpha-HPV, blue; any beta-HPV, orange; and any gamma-HPV, green.
Figure 3.
Figure 3.
Epidemiologic characteristics and risk of oral infection with alpha, beta, and gamma- human papillomavirus (HPV). The central symbols represent crude odds ratio and the lines indicate the 95% confidential interval from univariate analysis.
See this image and copyright information in PMC

References

    1. World Health Organization International Agency for Research on Cancer. IARC monographs on the evaluation of carcinogenic risks to humans. Human Papillomaviruses. Vol 90 Lyon: IARC, 2007.
    1. Chaturvedi AK, Engels EA, Anderson WF, Gillison ML. Incidence trends for human papillomavirus-related and -unrelated oral squamous cell carcinomas in the United States. J Clin Oncol 2008; 26:612–9. - PubMed
    1. Chaturvedi AK, Engels EA, Pfeiffer RM et al. . Human papillomavirus and rising oropharyngeal cancer incidence in the United States. J Clin Oncol 2011; 29:4294–301. - PMC - PubMed
    1. Chaturvedi AK, Anderson WF, Lortet-Tieulent J et al. . Worldwide trends in incidence rates for oral cavity and oropharyngeal cancers. J Clin Oncol 2013; 31:4550–9. - PMC - PubMed
    1. Huang H, Zhang B, Chen W et al. . Human papillomavirus infection and prognostic predictors in patients with oropharyngeal squamous cell carcinoma. Asian Pac J Cancer Prev 2012; 13:891–6. - PubMed

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