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Review
. 2018 Jul;42(3):248-254.
doi: 10.1016/j.jgr.2017.04.009. Epub 2017 May 15.

Functional role of ginseng-derived compounds in cancer

Akash Ahuja  1 , Ji Hye Kim  1 , Jong-Hoon Kim  2 , Young-Su Yi  3 , Jae Youl Cho  1
Affiliations
Review

Functional role of ginseng-derived compounds in cancer

Akash Ahuja et al. J Ginseng Res. 2018 Jul.

Abstract

Ginseng is a natural product best known for its curative properties in diverse physiological processes such as cancer, neurodegenerative disorders, hypertension, and maintenance of hemostasis in the immune system. In previous decades, there have been some promising studies into the pharmacology and chemistry of ginseng components and the relationship between their structure and function. The emerging use of modified ginseng and development of new compounds from ginseng for clinical studies have been topics of study for many researchers. The present review deals with the anticancer, anti-inflammatory, antioxidant, and chemopreventive effects, and recent advances in microRNA technology related to red ginseng. The review also summarizes the current knowledge on the effect of ginsenosides in the treatment of cancer.

Keywords: Panax ginseng; anticancer activity; ginseng-derived compounds; ginsenosides.

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Figures

Fig. 1
Fig. 1
Classification and chemical structure of ginsenosides based on sugar attachments on the skeleton and R groups of ginsenosides. (A) Protopanaxatriol, (B) protopanaxadiol, (C) oleanolic acid, and (D) ocotillol.
Fig. 2
Fig. 2
Major groups of Panax Ginseng along with new compounds isolated from Ginseng, their biological and anti-cancerous activity against different cell lines.
See this image and copyright information in PMC

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