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Meta-Analysis
. 2018 Jul 9;7(7):CD011151.
doi: 10.1002/14651858.CD011151.pub3.

Intraoperative use of low volume ventilation to decrease postoperative mortality, mechanical ventilation, lengths of stay and lung injury in adults without acute lung injury

Joanne Guay  1 , Edward A Ochroch, Sandra Kopp
Affiliations
Meta-Analysis

Intraoperative use of low volume ventilation to decrease postoperative mortality, mechanical ventilation, lengths of stay and lung injury in adults without acute lung injury

Joanne Guay et al. Cochrane Database Syst Rev. .

Abstract

Background: Since the 2000s, there has been a trend towards decreasing tidal volumes for positive pressure ventilation during surgery. This an update of a review first published in 2015, trying to determine if lower tidal volumes are beneficial or harmful for patients.

Objectives: To assess the benefit of intraoperative use of low tidal volume ventilation (less than 10 mL/kg of predicted body weight) compared with high tidal volumes (10 mL/kg or greater) to decrease postoperative complications in adults without acute lung injury.

Search methods: We searched the Cochrane Central Register of Controlled Trials (CENTRAL 2017, Issue 5), MEDLINE (OvidSP) (from 1946 to 19 May 2017), Embase (OvidSP) (from 1974 to 19 May 2017) and six trial registries. We screened the reference lists of all studies retained and of recent meta-analysis related to the topic during data extraction. We also screened conference proceedings of anaesthesiology societies, published in two major anaesthesiology journals. The search was rerun 3 January 2018.

Selection criteria: We included all parallel randomized controlled trials (RCTs) that evaluated the effect of low tidal volumes (defined as less than 10 mL/kg) on any of our selected outcomes in adults undergoing any type of surgery. We did not retain studies with participants requiring one-lung ventilation.

Data collection and analysis: Two authors independently assessed the quality of the retained studies with the Cochrane 'Risk of bias' tool. We analysed data with both fixed-effect (I2 statistic less than 25%) or random-effects (I2 statistic greater than 25%) models based on the degree of heterogeneity. When there was an effect, we calculated a number needed to treat for an additional beneficial outcome (NNTB) using the odds ratio. When there was no effect, we calculated the optimum information size.

Main results: We included seven new RCTs (536 participants) in the update.In total, we included 19 studies in the review (776 participants in the low tidal volume group and 772 in the high volume group). There are four studies awaiting classification and three are ongoing. All included studies were at some risk of bias. Participants were scheduled for abdominal surgery, heart surgery, pulmonary thromboendarterectomy, spinal surgery and knee surgery. Low tidal volumes used in the studies varied from 6 mL/kg to 8.1 mL/kg while high tidal volumes varied from 10 mL/kg to 12 mL/kg.Based on 12 studies including 1207 participants, the effects of low volume ventilation on 0- to 30-day mortality were uncertain (risk ratio (RR) 0.80, 95% confidence interval (CI) 0.42 to 1.53; I2 = 0%; low-quality evidence). Based on seven studies including 778 participants, lower tidal volumes probably reduced postoperative pneumonia (RR 0.45, 95% CI 0.25 to 0.82; I2 = 0%; moderate-quality evidence; NNTB 24, 95% CI 16 to 160), and it probably reduced the need for non-invasive postoperative ventilatory support based on three studies including 506 participants (RR 0.31, 95% CI 0.15 to 0.64; moderate-quality evidence; NNTB 13, 95% CI 11 to 24). Based on 11 studies including 957 participants, low tidal volumes during surgery probably decreased the need for postoperative invasive ventilatory support (RR 0.33, 95% CI 0.14 to 0.77; I2 = 0%; NNTB 39, 95% CI 30 to 166; moderate-quality evidence). Based on five studies including 898 participants, there may be little or no difference in the intensive care unit length of stay (standardized mean difference (SMD) -0.06, 95% CI -0.22 to 0.10; I2 = 33%; low-quality evidence). Based on 14 studies including 1297 participants, low tidal volumes may have reduced hospital length of stay by about 0.8 days (SMD -0.15, 95% CI -0.29 to 0.00; I2 = 27%; low-quality evidence). Based on five studies including 708 participants, the effects of low volume ventilation on barotrauma (pneumothorax) were uncertain (RR 1.77, 95% CI 0.52 to 5.99; I2 = 0%; very low-quality evidence).

Authors' conclusions: We found moderate-quality evidence that low tidal volumes (defined as less than 10 mL/kg) decreases pneumonia and the need for postoperative ventilatory support (invasive and non-invasive). We found no difference in the risk of barotrauma (pneumothorax), but the number of participants included does not allow us to make definitive statement on this. The four studies in 'Studies awaiting classification' may alter the conclusions of the review once assessed.

PubMed Disclaimer

Conflict of interest statement

JG: I receive fees as an Associate Professor for a course on airway management at the University of Quebec in Abitibi‐Temiscamingue.

EO: I have had no direct relationship with any equipment manufacturer or pharmaceutical company since 2007. I do not hold any stocks or shares other than mutual funds. I have participated as an expert witness in medical legal cases and patent cases.

Sandra Kopp: no conflict of interest.

Figures

1
1
Diagram of the flow search. RCT: randomized controlled trial. The original search (2014) performed for the first published version (2015) was rerun 19 May 2017. *A search with a modified strategy was run 8 January 2018: one trial classified as ongoing has been published is now awaiting classification. We found two new trials published between May 2017 and January 2018 and added them to the list of studies awaiting classification.
2
2
Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
3
3
Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
4
4
Mortality. Duval and Tweedie's trim and fill analysis. Actual results displayed in blue. Results corrected for the possibility of a publication bias displayed in red. The impact of asymmetry in the funnel plot led to a trim and fill estimate that would not change the conclusion, that is, there would still not be a difference for mortality between the two interventions (red lozenge).
5
5
Pneumonia. Duval and Tweedie's trim and fill analysis. Actual results displayed in blue. Results corrected for the possibility of a publication bias displayed in red. The impact of asymmetry in the funnel plot led to a trim and fill estimate that would not change the conclusion, that is, low tidal volumes would still decrease the incidence of pneumonia (red lozenge).
6
6
Meta‐regression. Intensive care unit length of stay versus low tidal volume values. The effect size was inversely correlated with the tidal volume administered in the low tidal volume groups. P = 0.02
1.1
1.1. Analysis
Comparison 1 Low versus high tidal volume, Outcome 1 Mortality within 30 days.
1.2
1.2. Analysis
Comparison 1 Low versus high tidal volume, Outcome 2 Pneumonia.
1.3
1.3. Analysis
Comparison 1 Low versus high tidal volume, Outcome 3 Need for postoperative non‐invasive ventilation.
1.4
1.4. Analysis
Comparison 1 Low versus high tidal volume, Outcome 4 Need for postoperative invasive ventilation.
1.5
1.5. Analysis
Comparison 1 Low versus high tidal volume, Outcome 5 Intensive care unit length of stay (days).
1.6
1.6. Analysis
Comparison 1 Low versus high tidal volume, Outcome 6 Hospital length of stay divided in subgroups according to positive end‐expiratory pressure (PEEP) use (days).
1.7
1.7. Analysis
Comparison 1 Low versus high tidal volume, Outcome 7 Hospital length of stay divided in subgroups according to recruitment manoeuvres or not (days).
1.8
1.8. Analysis
Comparison 1 Low versus high tidal volume, Outcome 8 Pneumothorax.
See this image and copyright information in PMC

Update of

References

References to studies included in this review

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Akca 2013 {published data only}
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References to studies awaiting assessment

Asida 2015 {published data only}
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References to ongoing studies

ACTRN12614000790640 {published data only}
    1. ACTRN12614000790640. A prospective randomised trial of two tidal volume ventilator strategies in patients undergoing major surgery. www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=366752&isRe... Date first received: 24 July 2014.
NCT01003730 {published data only}
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NCT03157479 {published data only}
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References to other published versions of this review

Guay 2015
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