Interventions for recurrent corneal erosions

Abstract

Background: Recurrent corneal erosion is a common cause of disabling ocular symptoms and predisposes the cornea to infection. It may follow corneal trauma. Measures to prevent the development of recurrent corneal erosion following corneal trauma have not been firmly established. Once recurrent corneal erosion develops, simple medical therapy (standard treatment) may lead to resolution of the episode. However, some people continue to suffer when such therapy fails and repeated episodes of erosion develop. A number of treatment and prophylactic options are then available but there is no agreement as to the best option. This review version is an update to the original version published in 2007 and a previous update published in 2012.

Objectives: To assess the effectiveness and adverse effects of regimens for the prophylaxis of further recurrent corneal erosion episodes, the treatment of recurrent corneal erosion and prophylaxis of the development of recurrent corneal erosion following trauma.

Search methods: We searched CENTRAL, which contains the Cochrane Eyes and Vision Trials Register; MEDLINE; Embase; LILACS; the ISRCTN registry; ClinicalTrials.gov and the ICTRP. The date of the search was 14 December 2017.

Selection criteria: We included randomised and quasi-randomised trials that compared a prophylactic or treatment regimen with another prophylaxis/treatment or no prophylaxis/treatment for people with recurrent corneal erosion.

Data collection and analysis: We used standard methods expected by Cochrane. Two authors independently screened search results, extracted data and assessed risk of bias in the included studies using the Cochrane tool for assessing risk of bias. We considered the following outcome measures: resolution of symptoms after treatment; recurrence after complete or partial resolution; symptoms (pain); adverse effects (corneal haze, astigmatism). We graded the certainty of the evidence using GRADE for the three most clinically relevant comparisons.

Main results: We included eight randomised and two quasi-randomised controlled trials in the review, encompassing 505 participants. Seven studies were from Europe (Germany, Sweden and the UK), two from East Asia (Hong Kong and Japan) and one from Australia. Nine of the studies examined treatments for episodes of recurrent corneal erosions and one study considered prophylaxis to prevent development of recurrent corneal erosions after injury. Two of the nine treatment studies also enrolled participants in a study of prophylaxis to prevent further episodes of recurrent corneal erosions. The studies were poorly reported; we judged only one study low risk of bias on all domains.Two studies compared therapeutic contact lens with topical lubrication but one of these studies was published over 30 years ago and used a therapeutic contact lens that is no longer in common use. The more recent study was a two-centre UK study with 29 participants. It provided low-certainty evidence on resolution of symptoms after treatment with similar number of participants in both groups experiencing resolution of symptoms at four months (risk ratio (RR) 0.97, 95% confidence interval (CI) 0.62 to 1.53). There was very low-certainty evidence on recurrence after partial or total resolution at seven months' follow-up (RR 1.07, 95% CI 0.07 to 15.54). There was no evidence of an important difference in pain score (score of 3 in the contact lens group and score of 2 in the topical lubrication group, low-certainty evidence) and no adverse effects were reported. The older study, using a contact lens no longer in common use, found an increased risk of pain and complications with the contact lens compared with hypromellose drops and paraffin ointment at night.A single-centre, Australian study, with 33 participants, provided low-certainty evidence of an increased risk of recurrence with phototherapeutic keratectomy compared with alcohol delamination but with wide confidence intervals, compatible with increased or decreased risk (RR 1.27, 95% CI 0.48 to 3.37). Time to recurrence was similar in both groups (6.5 and 6 months, low-certainty evidence). On average people receiving phototherapeutic keratectomy reported less pain but confidence intervals included no difference or greater pain (mean difference (MD) -0.70, 95% CI -2.23 to 0.83, low-certainty evidence). No adverse effects were reported.A 48-participant study in Hong Kong found recurrences were less common in people given diamond burr superficial keratectomy after epithelial debridement compared with sham diamond burr treatment after epithelial debridement (RR 0.07, 95% CI 0.01 to 0.50, moderate-certainty evidence). The study did not report pain scores but adverse effects such as corneal haze (RR 0.92, 95% CI 0.06 to 13.87, low-certainty evidence) and astigmatism (0.88 versus 0.44 dioptres, moderate-certainty evidence) were similar between the groups.A study comparing transepithelial versus subepithelial excimer laser ablation in 100 people found low-certainty evidence of a small increased risk of recurrence of corneal erosion at one-year follow-up in people given the transepithelial compared with subepithelial technique, however, the confidence intervals were wide and compatible with increased or decreased risk (RR 1.20, 95% CI 0.58 to 2.48, low-certainty evidence). Other outcomes were not reported.Other treatment comparisons included in this review were only addressed by studies published two decades or more ago. The results of these studies were inconclusive: excimer laser ablation (after epithelial debridement) versus no excimer laser ablation (after epithelial debridement), epithelial debridement versus anterior stromal puncture, anterior stromal puncture versus therapeutic contact lens, oral oxytetracycline and topical prednisolone (in addition to 'standard therapy') versus oral oxytetracycline (in addition to 'standard therapy') versus 'standard therapy'.

Authors' conclusions: Well-designed, masked, randomised controlled trials using standardised methods are needed to establish the benefits of new and existing prophylactic and treatment regimes for recurrent corneal erosion. Studies included in this review have been of insufficient size and quality to provide firm evidence to inform the development of management guidelines. International consensus is also needed to progress research efforts towards evaluation of the major effective treatments for recurrent corneal erosions.

1

Study flow diagram

2

'Risk of bias' graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.

3

'Risk of bias' summary: review authors' judgements about each risk of bias item for each included study.

1.1. Analysis

Comparison 1 Therapeutic contact lens versus topical lubrication, Outcome 1 Resolution of symptoms after treatment.

1.2. Analysis

Comparison 1 Therapeutic contact lens versus topical lubrication, Outcome 2 Recurrence after partial or complete resolution.

1.3. Analysis

Comparison 1 Therapeutic contact lens versus topical lubrication, Outcome 3 Pain.

2.1. Analysis

Comparison 2 Phototherapeutic keratectomy (PTK) versus alcohol delamination (ALD), Outcome 1 Resolution of symptoms after treatment.

2.2. Analysis

Comparison 2 Phototherapeutic keratectomy (PTK) versus alcohol delamination (ALD), Outcome 2 Recurrence after partial or complete resolution.

2.3. Analysis

Comparison 2 Phototherapeutic keratectomy (PTK) versus alcohol delamination (ALD), Outcome 3 Pain score.

2.4. Analysis

Comparison 2 Phototherapeutic keratectomy (PTK) versus alcohol delamination (ALD), Outcome 4 Recurrence requiring further treatment.

3.1. Analysis

Comparison 3 Diamond burr superficial keratectomy versus epithelial debridement, Outcome 1 Recurrence after partial or complete resolution.

3.2. Analysis

Comparison 3 Diamond burr superficial keratectomy versus epithelial debridement, Outcome 2 Corneal haze.

4.1. Analysis

Comparison 4 Transepithelial verus subepithelial excimer laser ablation, Outcome 1 Recurrence of complete or partial resolution.

5.1. Analysis

Comparison 5 Excimer laser (after epithelial debridement) versus no excimer laser (after epithelial debridement), Outcome 1 Recurrence after partial or complete resolution.

5.2. Analysis

Comparison 5 Excimer laser (after epithelial debridement) versus no excimer laser (after epithelial debridement), Outcome 2 Symptoms (pain score).

5.3. Analysis

Comparison 5 Excimer laser (after epithelial debridement) versus no excimer laser (after epithelial debridement), Outcome 3 Recurrences requiring further treatment.

6.1. Analysis

Comparison 6 Topical lubrication versus no topical lubrication (prophylaxis), Outcome 1 Development of recurrent corneal erosions at 3 months.

6.2. Analysis

Comparison 6 Topical lubrication versus no topical lubrication (prophylaxis), Outcome 2 Development of recurrent corneal erosions at 3 months.