Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1985 Oct;62(1):136-42.

Monocyte function in intravenous drug abusers with lymphadenopathy syndrome and in patients with acquired immunodeficiency syndrome: selective impairment of chemotaxis

G Poli, B Bottazzi, R Acero, L Bersani, V Rossi, M Introna, A Lazzarin, M Galli, A Mantovani

Monocyte function in intravenous drug abusers with lymphadenopathy syndrome and in patients with acquired immunodeficiency syndrome: selective impairment of chemotaxis

G Poli et al. Clin Exp Immunol. 1985 Oct.

Abstract

We have investigated monocyte function in 17 intravenous drug abusers with the clinical and laboratory features of lymphadenopathy syndrome (LAS). LAS patients had normal numbers of circulating monocytes. Monocytes from LAS patients were comparable to cells from normal donors in terms of phagocytosis of latex beads, interleukin-1 secretion, O2- release and killing of antibody-sensitized lymphoma cells or actinomycin D pretreated WEHI 164 cells. In contrast 13 out of 17 LAS subjects tested in this respect as well as six out of nine AIDS patients showed a marked defect of monocyte chemotaxis. Thus monocytes from patients with LAS or AIDS have a selective defect of monocyte chemotaxis.

PubMed Disclaimer

References

    1. J Immunol. 1974 Nov;113(5):1562-7 - PubMed
    1. Clin Exp Immunol. 1985 Oct;62(1):128-35 - PubMed
    1. Cell Immunol. 1978 Jan;35(1):99-111 - PubMed
    1. J Exp Med. 1978 Jul 1;148(1):115-27 - PubMed
    1. J Immunol. 1980 Jun;124(6):2892-9 - PubMed

Publication types