Experimental Models of Cardiovascular Diseases: Overview

Abstract

Cardiovascular disease is one of the most common causes of deaths in clinics. Experimental models of cardiovascular diseases are essential to understand disease mechanism, to provide accurate diagnoses, and to develop new therapies. Large numbers of experimental models have been proposed and replicated by many laboratories in the past. Models with significant advantages are chosen and became more popular. Particularly, feasibility, reproducibility, and human disease resemblance are the common key factors for frequently used cardiovascular disease models. In this chapter, we provide a brief overview of these experimental models used for in vitro, in vivo, and in silico studies of cardiovascular diseases.

Keywords: Animal model; Cardiomyocyte; Electrophysiology; Heart failure; Large animals; Left ventricle; Modeling; Myocardial infarction; Pulmonary hypertension; Rodents.