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Review
. 2018 Jun 28:15:47.
doi: 10.1186/s12986-018-0283-x. eCollection 2018.

DNA methylation landscapes in the pathogenesis of type 2 diabetes mellitus

Zheng Zhou #  1 , Bao Sun #  2   3 , Xiaoping Li  1 , Chunsheng Zhu  1
Affiliations
Review

DNA methylation landscapes in the pathogenesis of type 2 diabetes mellitus

Zheng Zhou et al. Nutr Metab (Lond). .

Abstract

Although genetic variations and environmental factors are vital to the development and progression of type 2 diabetes mellitus (T2DM), emerging literature suggest that epigenetics, especially DNA methylation, play a key role in the pathogenesis of T2DM by affecting insulin secretion of pancreatic β cells and the body's resistance to insulin. Previous studies have elucidated how DNA methylation interacted with various factors in T2DM pathogenesis. This review summarized the role of related methylation genes in insulin-sensitive organs, such as pancreatic islets, skeletal muscle, liver, brain and adipose tissue, as well as peripheral blood cells, comparing the tissue similarity and specificity of methylated genes, aiming at a better understanding of the pathogenesis of T2DM and providing new ideas for the personalized treatment of this metabolism-associated disease.

Keywords: DNA methylation; Insulin resistance; Insulin secretion; Insulin-sensitive organs; T2DM.

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Conflict of interest statement

Not applicable.Each author meets the criteria for authorship and assumes the corresponding responsibility.The authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
DNA methylation alterations affected insulin secretion and insulin resistance in the development of T2DM
See this image and copyright information in PMC

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