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. 2018 Jul 2:14:31.
doi: 10.1186/s13223-018-0251-z. eCollection 2018.

A population-based epidemiological study of anaphylaxis using national big data in Korea: trends in age-specific prevalence and epinephrine use in 2010-2014

Kyunguk Jeong  1 , Jung-Dong Lee  2 , Dae Ryong Kang  2 , Sooyoung Lee  1
Affiliations

A population-based epidemiological study of anaphylaxis using national big data in Korea: trends in age-specific prevalence and epinephrine use in 2010-2014

Kyunguk Jeong et al. Allergy Asthma Clin Immunol. .

Abstract

Background: Previous reports on anaphylaxis in Asia are limited to relatively small-scale studies. We performed this study to identify the nationwide prevalence of anaphylaxis and epinephrine prescription rates by age groups.

Methods: The total number of patients, yearly and overall prevalence, percentage of emergency department visits, and epinephrine prescription rates were calculated for patients diagnosed with anaphylaxis based on the Korean National Health Insurance database from 2010 to 2014.

Results: The mean prevalence of anaphylaxis in Korea was 26.23 (95% confidence interval, CI 25.78-26.68) per 100,000 person-years during the 5 years. It increased from 20.55 (95% CI 20.15-20.10) in 2010 to 35.33 (95% CI 34.81-35.85) per 100,000 person-years in 2014. The average prevalence was > 35 per 100,000 person-years among 50-69 year-olds, and the mean crude prevalence in children was 22.3 (0-2 years), 17.3 (3-6 years), 12.1 (7-12 years), and 14.9 (13-17 years) per 100,000 person-years, respectively. The overall prevalence increased 1.7-fold, with the highest rate of increase in 0-2 years of age. The overall percentage of emergent anaphylaxis patients was 88.4%, and the prevalence of emergent anaphylaxis increased from 18.63 (95% CI 18.25-19.01) to 31.28 (95% CI 30.79-31.77) per 100,000 person-years. In-hospital epinephrine prescription rate increased from 31.5 to 39.7%.

Conclusions: The mean prevalence of anaphylaxis in Korea was 26.2 per 100,000 person-years during the study period. The total number of anaphylaxis patients increased 1.7-fold from 2010 to 2014, with the most noticeable increment being in young children.

Keywords: Anaphylaxis; Emergency; Epidemiology; International classification of diseases.

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Figures

Fig. 1
Fig. 1
Operational definition of anaphylaxis
Fig. 2
Fig. 2
a Yearly prevalence of anaphylaxis by age group in 2010–2014. b Percentage increase of anaphylaxis patients by age groups in 2014 compared to 2010
Fig. 3
Fig. 3
Average number of anaphylaxis patients by sex in 2010–2014
Fig. 4
Fig. 4
a Percentage of emergent anaphylaxis patients by age groups. b Yearly prevalence of emergent anaphylaxis patients by age group in 2010–2014
Fig. 5
Fig. 5
a In-hospital epinephrine administration among anaphylaxis patients. The percentages are calculated by dividing the number of anaphylaxis patients with epinephrine prescription in hospital in the age group by the total number of anaphylaxis patients in the age group, and then multiplying by 100. b Percentage increase of in-hospital epinephrine administration among anaphylaxis patients in 2014 compared to 2010
See this image and copyright information in PMC

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