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Review
. 2018 Jul 3:13:23.
doi: 10.1186/s13027-018-0194-5. eCollection 2018.

The current role and future prospectives of functional parameters by diffusion weighted imaging in the assessment of histologic grade of HCC

Vincenza Granata  1 , Roberta Fusco  1   2 , Salvatore Filice  1 , Orlando Catalano  1 , Mauro Piccirillo  2 , Raffaele Palaia  2 , Francesco Izzo  2 , Antonella Petrillo  1
Affiliations
Review

The current role and future prospectives of functional parameters by diffusion weighted imaging in the assessment of histologic grade of HCC

Vincenza Granata et al. Infect Agent Cancer. .

Abstract

Hepatocellular carcinoma (HCC) is one of the most common human solid malignancies worldwide. Although the MRI is the technique that is best adapted to characterize HCC, there is not an agreement regarding the study protocol and even what the role of Diffusion-weighted imaging (DWI). The possibility that imaging study can correlate to histologic grade to selecting the therapeutic strategy would be valuable in helping to direct the proper management of HCC. Apparent Diffusion Coefficient (ADC) and IVIM-derived perfusion fraction (fp) and tissue diffusivity (Dt) values of HCC showed significantly better diagnostic performance in differentiating high-grade HCC from low-grade HCC, and significant correlation was observed between ADC, fp, Dt and histological grade.

Keywords: Diffusion weighted imaging; HCC; Histologic grade; Magnetic resonance imaging.

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Conflict of interest statement

Not applicable.Not applicable.The authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Included and excluded studies in systematic review
Fig. 2
Fig. 2
High-grade HCC. DWI sequences: in A b50 s/mm2; in B b800 s/mm2 and in C ADC map
Fig. 3
Fig. 3
Low-grade HCC. DWI sequences: in A b50 s/mm2; in B b800 s/mm2 and in C ADC map
See this image and copyright information in PMC

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