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. 2004 Aug 31;15(3):82-85.
eCollection 2004 Aug.

Neuroimmunology: Immunoglobulins and the Intrathecal Polyspecific Immune Response in Acute, Subacute and Chronic Neurological Diseases

Hansotto Reiber  1
Affiliations

Neuroimmunology: Immunoglobulins and the Intrathecal Polyspecific Immune Response in Acute, Subacute and Chronic Neurological Diseases

Hansotto Reiber. EJIFCC. .
No abstract available

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Figures

Figure 1.
Figure 1.
Isoelectric focussing on agarose gels with immunoblot: The figure represents the classical types 1 – 5 (Andersson et al. 1994):

  1. Type 1: No bands in CSF and serum.

  2. Type 2: Oligoclonal IgG-bands in CSF, not in serum. Interpretation: Intrathecal IgG-synthesis.

  3. Type 3: Oligoclonal bands in CSF (like type 2) and additional identical oligoclonal bands in CSF and serum (like type 4). Interpretation: Intrathecal IgG-synthesis

  4. Type 4: Identical oligoclonal bands in CSF and serum. Interpretation: No intrathecal IgG-synthesis but systemic immune reaction.

  5. Type 5: Monoclonal bands in CSF and serum. Interpretation: Systemic paraproteinaemia.

Figure 2.
Figure 2.
Isoelectric focussing on polyacrylamidgel with silverstain: In contrast to the immune detection (Fig. 1) we find in the protein stain the albumin range (also place for application of the samples) at about pH = 5.0. In the alcaline range (at pH 9.3) we find cystatin C (gamma-trace-protein) as a single band in CSF (CSF marker).
See this image and copyright information in PMC

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