Alternating Electric Fields (“Tumour-Treating Fields”) for the Treatment of Glioblastoma
- PMID: 29989769
- Bookshelf ID: NBK513128
Alternating Electric Fields (“Tumour-Treating Fields”) for the Treatment of Glioblastoma
Excerpt
Glioblastoma is the most common type of primary brain cancer in adults.
Despite advances in treatment, life expectancy for patients with glioblastoma is typically less than two years.
Optune is a wearable technology intended for use in addition to standard therapies ― surgical resection, radiation therapy, and chemotherapy ― in adults with either newly diagnosed or recurrent glioblastoma. It has also been trialled as a single therapy for adult patients with recurrent glioblastoma.
Optune delivers alternating electric fields, or “tumour-treating fields,” to the brain to disrupt cancer cell division.
The evidence suggests that some patients with newly diagnosed glioblastoma treated with Optune may live longer, although which patients are most likely to benefit is not yet entirely clear.
The cost of therapy with the Optune system is about US$21,000 per patient, per month.
Copyright © CADTH 2018. You are permitted to reproduce this document for non-commercial purposes, provided it is not modified when reproduced and appropriate credit is given to CADTH.
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References
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- Optune® patient information and operation manual [Internet] Jersey (GB): Novocure; 2017. May, [cited 2017 Sep 20]. Available from: https://www.optune.com/Content/pdfs/Optune_PIOM_8.5x11.pdf.
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- Brain tumour facts [Internet] London (ON): Brain Tumour Foundation of Canada; 2017. [cited 2017 Aug 31]. Available from: http://www.braintumour.ca/2494/brain-tumour-facts.
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- National Comprehensive Cancer Network. Central nervous system cancers [Internet]. Version 1.2017. Fort Washington (PA): NCCN; 2017. Aug 18, [cited 2017 Dec 4]. (NCCN clinical practice guidelines in oncology). Available from: https://www.nccn.org/professionals/physician_gls/pdf/cns.pdf Registration required.
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- Toms SA, Tapinos N. Recent advances in the treatment of gliomas - comprehensive brain tumor center. R I Med J. 2017 Jun 1;100(6):43–6. - PubMed
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- Gerstel J. Rethinking the brain and glioblastoma. Globe and Mail [Internet] 2017. Apr 26, [cited 2017 Aug 28]. Available from: https://www.theglobeandmail.com/life/health-and-fitness/advsunnybrook/re...
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