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Comment
. 2018 Jul 9;34(1):3-5.
doi: 10.1016/j.ccell.2018.06.011.

EZH2 Inactivates Primary Cilia to Activate Wnt and Drive Melanoma

Peter K Jackson  1
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EZH2 Inactivates Primary Cilia to Activate Wnt and Drive Melanoma

Peter K Jackson. Cancer Cell. .
Free article

Abstract

EZH2 is frequently amplified in human melanomas. In this issue of Cancer Cell, Zingg et al. find that EZH2 overexpression silences genes for the primary cilium, causing deciliation, Wnt pathway activation, and progression of BrafV600E- or NrasQ61N-driven melanomas, thus defining a tumor-suppressor role for cilia in cancer.

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  • EZH2-Mediated Primary Cilium Deconstruction Drives Metastatic Melanoma Formation.
    Zingg D, Debbache J, Peña-Hernández R, Antunes AT, Schaefer SM, Cheng PF, Zimmerli D, Haeusel J, Calçada RR, Tuncer E, Zhang Y, Bossart R, Wong KK, Basler K, Dummer R, Santoro R, Levesque MP, Sommer L. Zingg D, et al. Cancer Cell. 2018 Jul 9;34(1):69-84.e14. doi: 10.1016/j.ccell.2018.06.001. Epub 2018 Jun 28. Cancer Cell. 2018. PMID: 30008323

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