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Case Reports
. 2018 May 27:2018:8532081.
doi: 10.1155/2018/8532081. eCollection 2018.

Pregnancy Complications in a-Thalassemia (Hemoglobinopathy H): A Case Study

Marianna Politou  1 , Giorgos Dryllis  1 , Maria Efstathopoulou  1 , Serena Valsami  1 , Faidra-Evangelia Triantafyllou  1 , Athanasia Tsaroucha  2 , Antonios Kattamis  3 , Nikos F Vlahos  4
Affiliations
Case Reports

Pregnancy Complications in a-Thalassemia (Hemoglobinopathy H): A Case Study

Marianna Politou et al. Case Rep Obstet Gynecol. .

Abstract

Thalassemia intermedia (TI) is a clinical definition which represents a wide spectrum of thalassemia genotypes but mainly includes patients who do not require or only occasionally require transfusion. An uncommon case of a 32-year-old Greek woman, para 1, at the 22nd week + day 3 of gestation with thalassemia intermedia (she was splenectomized), where her pregnancy was complicated with portal vein thrombosis, splenic thrombosis, and partial HELLP, is described. This is a generally uncommon event in thalassemia intermedia. She had no transfusion as her hematologist consulted and she took anticoagulation therapy. Thus, we present for the first time in the literature a case of HbH a-thalassemia pregnant woman whose pregnancy was complicated with portal vein thrombosis, splenic vein thrombosis, and partial HELLP; she was treated with anticoagulation therapy and she had a successful outcome.

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References

    1. Vichinsky E. P. Clinical manifestations of α-thalassemia. Cold Spring Harbor Perspectives in Medicine. 2013;3(5):p. a011742. doi: 10.1101/cshperspect.a011742. - DOI - PMC - PubMed
    1. Kanavakis E., Papassotiriou I., Karagiorga M., et al. Phenotypic and molecular diversity of haemoglobin H disease: a Greek experience. British Journal of Haematology. 2000;111(3):915–923. doi: 10.1046/j.1365-2141.2000.02448.x. - DOI - PubMed
    1. Voskaridou E., Balassopoulou A., Boutou E., et al. Pregnancy in beta-thalassemia intermedia: 20-year experience of a Greek thalassemia center. European Journal of Haematology. 2014;93(6):492–499. doi: 10.1111/ejh.12387. - DOI - PubMed
    1. Cappelini M. D., Musallam K. M., Pogiiiali E., Taher A. T. Hypercoagulability in non –tranfusion –dependent thalassemia. Blood Reviews. 2012;6 Suppl 1:S20–S23. - PubMed
    1. Vichinsky E. P. Alpha thalassemia major--new mutations, intrauterine management, and outcomes. Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. 2009:35–41. - PubMed

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