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Editorial
. 2018 Aug 15;198(4):419-422.
doi: 10.1164/rccm.201803-0586ED.

Of Mice and Men . . . and Microbes: Conclusions and Cautions from a Murine Study of the Lung Microbiome and Microbiome-Immune Interactions

John E McGinniss  1 , Ronald G Collman  1
Affiliations
Editorial

Of Mice and Men . . . and Microbes: Conclusions and Cautions from a Murine Study of the Lung Microbiome and Microbiome-Immune Interactions

John E McGinniss et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
(A) Mouse lung tissues harbor bacterial sequences indicating a distinct microbiome, although the density relative to background or high-microbe niches is unclear. (B) The microbiome is dynamic, and strongly impacted by environmental factors, so specific findings may be unique to a particular model and require caution in assuming generalizability. (C) The lung microbiome composition correlates with lung levels of IL-1α and IL-4, whereas oral and cecal microbiomes correlate with lung IL-4 only, indicating both lung–lung and gut–lung microbiome–immune relationships. (D) The source from which the mouse lung microbiome is seeded, and that mediates environmental influences, is undetermined. Illustration by Jacqueline Schaffer.
See this image and copyright information in PMC

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References

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