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. 1985;174(4):167-75.
doi: 10.1007/BF02123693.

Augmentation of the neutralisation test for type 1 HSV: evidence of high representation of neutralising antibody in the adult community

Augmentation of the neutralisation test for type 1 HSV: evidence of high representation of neutralising antibody in the adult community

P J Holmes et al. Med Microbiol Immunol. 1985.

Abstract

Optimal neutralisation of type 1 herpes simplex virus was obtained by reacting undiluted human serum with virus for 4 h at 37 degrees C, followed by addition of antihuman globulin for 20 min; under these conditions it was possible to detect neutralising antibody activity in 40 of 45 human sera (88%) previously adjudged to be negative by conventional neutralisation tests.

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