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Review
. 2018 Jul 11;18(1):318.
doi: 10.1186/s12879-018-3232-4.

Relationship between Helicobacter pylori and Rosacea: review and discussion

Xingzhe Yang  1
Affiliations
Review

Relationship between Helicobacter pylori and Rosacea: review and discussion

Xingzhe Yang. BMC Infect Dis. .

Abstract

Background: Rosacea is an inflammatory disease affecting the central part of face characterized by persistent or recurrent episodes of erythema, papules, pustules and telangiectasias of unknown etiology. Helicobacter pylori (H. pylori) is a gram-negative bacillus, which is one of the main causes of chronic gastritis, gastric cancer and gastrointestinal ulcers. Recent evidences have suggested that H. pylori infection is closely related to the occurrence of diseases. In recent years, studies have found that Helicobacter pylori infection is associated with the occurrence of acne rosacea. So the treatment of Helicobacter pylori infection may be a therapeutic method of acne rosacea. But it continues to be controversial. In other studies, the treatment of Helicobacter pylori did not significantly reduce the severity of acne rosacea. To further explore the association between acne rosacea and Helicobacter pylori infection, a summarize method was used to study the relationship between acne rosacea and Helicobacter pylori, providing reference for clinical acne rosacea therapy.

Methods: Systematic searches were conducted on Wanfang Data, CQVIP, Springer, Public Health Management Corporation (PHMC), CNKI, and Pubmed, from January 1,2008 to Mar. 1, 2018, using Helicobacter pylori and rosacea to retrieve the literature. Depending on the inclusion and exclusion criteria, 27 articles considered or confirmed the correlation between H. pylori and rosacea.

Results: Epidemiological investigations and experiments have confirmed that H. pylori infection is associated with the development of rosacea. The effect of anti-H. pylori therapy is better than the routine therapy for rosacea. H. pylori can stimulate the immune system to produce a large number of inflammatory mediators, leading to the occurrence and aggravation of rosacea inflammation.

Conclusions: It is confirmed that H. pylori infection is involved in the development of rosacea. It is suggested that rosacea patients should be tested for H. pylori infection, the H. pylori-positive rosacea patients should be treated with eradication of H. pylori, so as to enhance the therapeutic effect of rosacea. This study adds that H. pylori infection is involved in the development of rosacea. Epidemiological investigations and experiments have confirmed the rationality. The effect of anti-H. pylori therapy is better than the routine therapy for rosacea. H. pylori-positive rosacea patients should be treated with the therapeutic method of eradication of H. pylori.

Keywords: Anti-H. pylori therapy; Correlation; Epidemiological investigation; Experiment; Helicobacter pylori; Mechanism; Related; Rosacea.

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Conflict of interest statement

Ethics approval

Given the study was a comprehensive research rather than animal experimental research, no need for the approval of the ethics committee. The findings and conclusions in this report are those of the author and do not necessarily represent the official position of BMC Infectious Diseases.

Consent for publication

Not applicable.

Competing interests

The author declares that he/she has no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Preferred reporting items for H. pylori and rosacea. Systematic searches were conducted in Wanfang Data, CQVIP, Springer, Public Health Management Corporation (PHMC), CNKI and Pubmed, from January 1st 2008 to Mar. 1, 2018, using Helicobacter pylori and rosacea to retrieve the literature. The total is 247:19 in Wanfang, 4 in CQVIP, 0 in Springer, 121 in PHMC, 2 in CNKI and 101 in Pubmed. According to the inclusion and exclusion criteria, 27 articles considered or confirmed the correlation between H. pylori and rosacea.
Fig. 2
Fig. 2
Mechanism of H. pylori infection in relation to rosacea. The sequential therapy with the combination between Chinese and western medicine could effectively relieve the clinical symptoms of H. pylori-positive AR patients with spleen-stomach dampness-heat, and the mechanism of which is probably related to the decrease of H. pylori -positive rate and serum levels of IL- 8 and TNF- α
See this image and copyright information in PMC

References

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