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Comment
. 2018 Aug;21(3):e11.
doi: 10.1136/ebmental-2018-300003. Epub 2018 Jul 11.

Clozapine and long-acting injectable antipsychotics reduce hospitalisation and treatment failure risk in patients with schizophrenia

Jose M Rubio  1   2   3 , Christoph U Correll  1   2   3   4
Affiliations
Comment

Clozapine and long-acting injectable antipsychotics reduce hospitalisation and treatment failure risk in patients with schizophrenia

Jose M Rubio et al. Evid Based Ment Health. 2018 Aug.
No abstract available

Keywords: adult psychiatry.

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Conflict of interest statement

Competing interests: JMR has been an advisor for Lundbeck. CUC has been a consultant and/or advisor to or has received honoraria from Alkermes, Allergan, Angelini, Gerson Lehrman Group, IntraCellular Therapies, Janssen/J&J, LB Pharma, Lundbeck, Medavante, Medscape, Merck, Neurocrine, Otsuka, Pfizer, ROVI, Servier, Sunovion, Takeda and Teva. He has provided expert testimony for Bristol-Myers Squibb, Janssen and Otsuka. He served on a Data Safety Monitoring Board for Lundbeck, ROVI and Teva. He received royalties from UpToDate and grant support from Janssen and Takeda. He is also a shareholder of LB Pharma.

Comment on

References

    1. Leucht S, Cipriani A, Spineli L, et al. . Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis. Lancet 2013;382:951–62. 10.1016/S0140-6736(13)60733-3 - DOI - PubMed
    1. Samara MT, Dold M, Gianatsi M, et al. . Efficacy, acceptability, and tolerability of antipsychotics in treatment-resistant schizophrenia: a network meta-analysis. JAMA Psychiatry 2016;73:199–210. 10.1001/jamapsychiatry.2015.2955 - DOI - PubMed
    1. Kishimoto T, Hagi K, Nitta M, et al. . Effectiveness of long-acting injectable vs oral antipsychotics in patients with schizophrenia: a meta-analysis of prospective and retrospective cohort studies. Schizophr Bull 2018;44:603–19. 10.1093/schbul/sbx090 - DOI - PMC - PubMed
    1. Kane JM, Kishimoto T, Correll CU. Assessing the comparative effectiveness of long-acting injectable vs. oral antipsychotic medications in the prevention of relapse provides a case study in comparative effectiveness research in psychiatry. J Clin Epidemiol 2013;66(8 Suppl):S37–41. 10.1016/j.jclinepi.2013.01.012 - DOI - PMC - PubMed
    1. Tiihonen J, Mittendorfer-Rutz E, Majak M, et al. . Real-world effectiveness of antipsychotic treatments in a nationwide cohort of 29 823 patients with Schizophrenia. JAMA Psychiatry 2017;74:686–93. 10.1001/jamapsychiatry.2017.1322 - DOI - PMC - PubMed