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Editorial
. 2018 Jul;11(7):e002248.
doi: 10.1161/CIRCGEN.118.002248.

Rare and Low-Frequency Variant of ARHGEF17 Is Associated With Intracranial Aneurysms

Li He  1 , Richard W Pierce  2 , Wang Min  3   2
Affiliations
Editorial

Rare and Low-Frequency Variant of ARHGEF17 Is Associated With Intracranial Aneurysms

Li He et al. Circ Genom Precis Med. 2018 Jul.
No abstract available

Keywords: Editorials; cerebrovascular disorders; genomics; intracranial aneurysm; risk factors.

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Figures

Figure 1
Figure 1
A. Schematic illustration of the discovery and function of rare and low-frequency variant of ARHGEF17 in IAs. Next generation sequencing technology was used to detect the rare and low-frequency variants in 20 Chinese familial and sporadic IA patients, after replication and risk gene prioritization analysis, ARHGEF17 was considered as a risk gene of IAs. B. ARHGEF17 deficiency induced intracranial bleeding and vascular leakage in zebrafish. The mechanism by which ARHGEF17 mediates this process needs to be further defined. IAs, intracranial aneurysms, EC, endothelial cell.
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