. 2019 Mar;21(3):743-747.

doi: 10.1038/s41436-018-0080-y. Epub 2018 Jul 12.

Opportunities to implement a sustainable genomic medicine program: lessons learned from the IGNITE Network

Affiliations

¹ Indiana University School of Medicine Indianapolis, Indianapolis, Indiana, USA. kdlevy@iu.edu.
² Nemours Children's Specialty Care Jacksonville, Jacksonville, Florida, USA.
³ Department of Biological Sciences, Dana and David Dornsife College of Letters, Arts, and Sciences, University of Southern California, Los Angeles, California, USA.
⁴ Nemours Children's Hospital University of Central Florida College of Medicine Orlando, Orlando, Florida, USA.
⁵ University of Maryland School of Pharmacy, Baltimore, Maryland, USA.
⁶ H. Lee Moffitt Cancer Center and Research Institute Tampa, Tampa, Florida, USA.
⁷ Department of Health Policy and Management, IU Fairbanks School of Public Health, IUPUI, Indianapolis, Indiana, USA.
⁸ Indiana University School of Medicine Indianapolis, Indianapolis, Indiana, USA.
⁹ National Human Genome Research Institute Bethesda, Bethesda, Maryland, USA.
¹⁰ Center for Applied Genomics & Precision Medicine, Duke University School of Medicine Durham, Durham, North Carolina, USA.
¹¹ Icahn School of Medicine at Mount Sinai New York, New York, New York, USA.

PMID: 29997387
PMCID: PMC6330142
DOI: 10.1038/s41436-018-0080-y

Opportunities to implement a sustainable genomic medicine program: lessons learned from the IGNITE Network

Kenneth D Levy et al. Genet Med. 2019 Mar.

. 2019 Mar;21(3):743-747.

doi: 10.1038/s41436-018-0080-y. Epub 2018 Jul 12.

Authors

Affiliations

¹ Indiana University School of Medicine Indianapolis, Indianapolis, Indiana, USA. kdlevy@iu.edu.
² Nemours Children's Specialty Care Jacksonville, Jacksonville, Florida, USA.
³ Department of Biological Sciences, Dana and David Dornsife College of Letters, Arts, and Sciences, University of Southern California, Los Angeles, California, USA.
⁴ Nemours Children's Hospital University of Central Florida College of Medicine Orlando, Orlando, Florida, USA.
⁵ University of Maryland School of Pharmacy, Baltimore, Maryland, USA.
⁶ H. Lee Moffitt Cancer Center and Research Institute Tampa, Tampa, Florida, USA.
⁷ Department of Health Policy and Management, IU Fairbanks School of Public Health, IUPUI, Indianapolis, Indiana, USA.
⁸ Indiana University School of Medicine Indianapolis, Indianapolis, Indiana, USA.
⁹ National Human Genome Research Institute Bethesda, Bethesda, Maryland, USA.
¹⁰ Center for Applied Genomics & Precision Medicine, Duke University School of Medicine Durham, Durham, North Carolina, USA.
¹¹ Icahn School of Medicine at Mount Sinai New York, New York, New York, USA.

PMID: 29997387
PMCID: PMC6330142
DOI: 10.1038/s41436-018-0080-y

Erratum in

Correction: Opportunities to implement a sustainable genomic medicine program: lessons learned from the IGNITE Network.
Levy KD, Blake K, Fletcher-Hoppe C, Franciosi J, Goto D, Hicks JK, Holmes AM, Kanuri SH, Madden EB, Musty MD, Orlando L, Pratt VM, Ramos M, Wu R, Ginsburg GS. Levy KD, et al. Genet Med. 2019 Jul;21(7):1670. doi: 10.1038/s41436-018-0280-5. Genet Med. 2019. PMID: 30158693 Free PMC article.
Correction: Opportunities to implement a sustainable genomic medicine program: lessons learned from the IGNITE Network.
Levy KD, Blake K, Fletcher-Hoppe C, Franciosi J, Goto D, Hicks JK, Holmes AM, Kanuri SH, Madden EB, Musty MD, Orlando L, Pratt VM, Ramos M, Wu R, Ginsburg GS. Levy KD, et al. Genet Med. 2020 Oct;22(10):1730. doi: 10.1038/s41436-020-0911-5. Genet Med. 2020. PMID: 32719393 Free PMC article.
Correction: Opportunities to implement a sustainable genomic medicine program: lessons learned from the IGNITE Network.
Levy KD, Blake K, Fletcher-Hoppe C, Franciosi J, Goto D, Hicks JK, Holmes AM, Kanuri SH, Madden EB, Musty MD, Orlando L, Pratt VM, Ramos M, Wu R, Ginsburg GS. Levy KD, et al. Genet Med. 2021 Oct;23(10):2020. doi: 10.1038/s41436-020-01054-0. Genet Med. 2021. PMID: 33288881 Free PMC article. No abstract available.

Abstract

Purpose: While there is growing scientific evidence for and significant advances in the use of genomic technologies in medicine, there is a significant lag in the clinical adoption and sustainability of genomic medicine. Here we describe the findings from the National Human Genome Research Institute's (NHGRI) Implementing GeNomics In pracTicE (IGNITE) Network in identifying key constructs, opportunities, and challenges associated with driving sustainability of genomic medicine in clinical practice.

Methods: Network members and affiliates were surveyed to identify key drivers associated with implementing and sustaining a genomic medicine program. Tallied results were used to develop and weigh key constructs/drivers required to support sustainability of genomic medicine programs.

Results: The top three driver-stakeholder dyads were (1) genomic training for providers, (2) genomic clinical decision support (CDS) tools embedded in the electronic health record (EHR), and (3) third party reimbursement for genomic testing.

Conclusion: Priorities may differ depending on healthcare systems when comparing the current state of key drivers versus projected needs for supporting genomic medicine sustainability. Thus we provide gap-filling guidance based on IGNITE members' experiences. Although results are limited to findings from the IGNITE network, their implementation, scientific, and clinical experience may be used as a road map by others considering implementing genomic medicine programs.

Keywords: Genomic education; Genomics; IGNITE Network; Implementation science; Sustainability.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

**Fig. 1. Seven key drivers of genomic sustainability across four primary stakeholders resulting in 28 constructs (dyads).**
EMR electronic medical record, CDS clinical decision support, LCME Liaison Committee on Medical Education, FDA Food and Drug Administration, RFA Request for Application, NIH National Institutes of Health

**Fig. 2**
Constructs weighted by frequency selected as being important in genomic sustainability (a), and frequency weighted in top three of importance (b).

See this image and copyright information in PMC

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Opportunities to implement a sustainable genomic medicine program: lessons learned from the IGNITE Network

Affiliations

Opportunities to implement a sustainable genomic medicine program: lessons learned from the IGNITE Network

Authors

Affiliations

Erratum in

Abstract

Conflict of interest statement

Figures

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Miscellaneous