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Review

Ursodiol

No authors listed
In: Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006.
.
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Review

Ursodiol

No authors listed.
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Excerpt

Ursodiol is naturally present in human milk. Because of the low levels of ursodiol (ursodeoxycholic acid) in breastmilk after exogenous administration, amounts ingested by the infant are small and are not expected to cause any adverse effects in breastfed infants.[1,2] Ursodiol has been given directly to newborns to safely and successfully treat prolonged neonatal jaundice.[3] No special precautions are required.

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References

    1. de Vries E, Beuers U. Ursodeoxycholic acid in pregnancy? J Hepatol 2019;71:1237-45. - PubMed
    1. Šimják P, Petr T, Kaslová B, et al. Ursodeoxycholic acid use in lactating female patients is associated with clinically negligible concentrations of this bile acid in breast milk. Sci Rep 2022;12:19543. - PMC - PubMed
    1. Ozdemir A, Kurtoglu S, Halis H, et al. An evaluation of ursodeoxycholic acid treatment in prolonged unconjugated hyperbilirubinemia due to breast milk. Niger J Clin Pract 2023;26:1226-33. - PubMed
    1. Rudi J, Schonig T, Stremmel W. [Therapy with ursodeoxycholic acid in primary biliary cirrhosis in pregnancy]. Z Gastroenterol 1996;34:188-91. - PubMed
    1. Brites D, Rodrigues CM. Elevated levels of bile acids in colostrum of patients with cholestasis of pregnancy are decreased following ursodeoxycholic acid therapy. J Hepatol 1998;29:743-51. - PubMed

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