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Review

Sodium Iodide I 131

No authors listed
In: Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006.
.
Free Books & Documents
Review

Sodium Iodide I 131

No authors listed.
Free Books & Documents

Excerpt

Information in this record refers to the use of sodium iodide I 131 as a diagnostic and therapeutic agent. The use of I 131 is contraindicated during lactation. Breastfeeding should be discontinued permanently for this child after administration of sodium iodide I 131 in a dose of 0.01 MBq (0.004 mCi) or greater to a nursing mother.[1-8] Ceasing breastfeeding 4 to 8 weeks before receiving a therapeutic dose of sodium iodide I 131 is recommended to reduce the radiation dose to the breasts and the risk of milk leakage that can contaminate clothing with radioactive iodine.[9-12] The American Thyroid Association recommends using I 123 or Tc99m pertechnetate scans for diagnosis of hyperthyroidism in nursing mothers.[1]

Parents should refrain from close contact with their infants after therapeutic iodine 131 administration. The exact duration depends on the dose administered, condition being treated, and source of the recommendation.[13,14] Recommended times range from 15 to 27 days after hyperthyroidism treatment, 16 to 24 days after ablation of thyroid cancer, and 4 to 5 days after follow-up therapy of thyroid ablation therapy.[14]

Nursing mothers should not work with substances containing I 131 in their workplace.[15]

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References

    1. Alexander E, Pearce E, Brent G, et al. 2016 Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease during Pregnancy and the Postpartum. Thyroid 2017;27:315-89. - PubMed
    1. Mountford P, O'Doherty M. Exposure of critical groups to nuclear medicine patients. Appl Radiat Isot 1999;50:89-111. - PubMed
    1. Silberstein E, Alavi A, Balon H, et al. The SNMMI practice guideline for therapy of thyroid disease with 131I 3.0. J Nucl Med 2012;53:1633-51. - PubMed
    1. Mattsson S, Johansson L, Leide Svegborn S, et al. Radiation dose to patients from radiopharmaceuticals: A compendium of current information related to frequently used substances. ICRP Publication 128. Annex D. Recommendations on breast-feeding interruptions. Ann ICRP 2015;44:7-321. doi:10.1177/0146645314558019 - DOI - PubMed
    1. International Atomic Energy Agency. Radiation Protection and Safety in Medical Uses of Ionizing Radiation, IAEA Safety Standards Series No. SSG-46, IAEA, Vienna. 2018. https://www.iaea.org/publications/11102/radiation-protection-and-safety-...

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