Sodium Iodide I 131
- PMID: 30000623
- Bookshelf ID: NBK501563
Sodium Iodide I 131
Excerpt
Information in this record refers to the use of sodium iodide I 131 as a diagnostic and therapeutic agent. The use of I 131 is contraindicated during lactation. Breastfeeding should be discontinued permanently for this child after administration of sodium iodide I 131 in a dose of 0.01 MBq (0.004 mCi) or greater to a nursing mother.[1-8] Ceasing breastfeeding 4 to 8 weeks before receiving a therapeutic dose of sodium iodide I 131 is recommended to reduce the radiation dose to the breasts and the risk of milk leakage that can contaminate clothing with radioactive iodine.[9-12] The American Thyroid Association recommends using I 123 or Tc99m pertechnetate scans for diagnosis of hyperthyroidism in nursing mothers.[1]
Parents should refrain from close contact with their infants after therapeutic iodine 131 administration. The exact duration depends on the dose administered, condition being treated, and source of the recommendation.[13,14] Recommended times range from 15 to 27 days after hyperthyroidism treatment, 16 to 24 days after ablation of thyroid cancer, and 4 to 5 days after follow-up therapy of thyroid ablation therapy.[14]
Nursing mothers should not work with substances containing I 131 in their workplace.[15]
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References
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- Alexander E, Pearce E, Brent G, et al. 2016 Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease during Pregnancy and the Postpartum. Thyroid 2017;27:315-89. - PubMed
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- Mountford P, O'Doherty M. Exposure of critical groups to nuclear medicine patients. Appl Radiat Isot 1999;50:89-111. - PubMed
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- Silberstein E, Alavi A, Balon H, et al. The SNMMI practice guideline for therapy of thyroid disease with 131I 3.0. J Nucl Med 2012;53:1633-51. - PubMed
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- Mattsson S, Johansson L, Leide Svegborn S, et al. Radiation dose to patients from radiopharmaceuticals: A compendium of current information related to frequently used substances. ICRP Publication 128. Annex D. Recommendations on breast-feeding interruptions. Ann ICRP 2015;44:7-321. doi:10.1177/0146645314558019 - DOI - PubMed
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- International Atomic Energy Agency. Radiation Protection and Safety in Medical Uses of Ionizing Radiation, IAEA Safety Standards Series No. SSG-46, IAEA, Vienna. 2018. https://www.iaea.org/publications/11102/radiation-protection-and-safety-...
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