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Review

Naloxone

No authors listed
In: Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006.
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Review

Naloxone

No authors listed.
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Excerpt

Naloxone is excreted into milk in very small amounts and is not detectable in the plasma of breastfed infants because of its very poor oral bioavailability. Routine use of naloxone in combination products is of no concern during breastfeeding. However, if naloxone is required by the mother for an opioid overdose, she should withhold nursing until the opioid is out of her system.

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References

    1. Jansson LM, McConnell K, Velez M, et al. Buprenorphine-naloxone maintenance and lactation. J Hum Lact 2024;40:113-9. - PubMed
    1. Cholst IN, Wardlaw SL, Newman CB, Frantz AG. Prolactin response to breast stimulation in lactating women is not mediated by endogenous opioids. Am J Obstet Gynecol 1984;150:558-61. - PubMed
    1. Johnson MR, Andrews MA, Seckl JR, Lightman SL. Effect of naloxone on neurohypophyseal peptide responses to breast feeding and breast stimulation in man. Clin Endocrinol (Oxf) 1990;33:81-6. - PubMed

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