Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review

Salsalate

No authors listed
In: Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006.
.
Free Books & Documents
Review

Salsalate

No authors listed.
Free Books & Documents

Excerpt

Salsalate has not been studied during breastfeeding, but salsalate results in salicylic acid in the blood. Salicylic acid and aspirin have been studied during breastfeeding. The excretion of salicylate into breastmilk increases disproportionately as the maternal dosage increases. Long-term, high-dose maternal aspirin ingestion probably caused metabolic acidosis in one breastfed infant. Reye’s syndrome is associated with aspirin administration to infants with viral infections, but the risk of Reye’s syndrome from salicylate in breastmilk is unknown. An alternate drug is preferred over salsalate.

PubMed Disclaimer

Similar articles

  • Choline Magnesium Salicylate.
    [No authors listed] [No authors listed] 2025 Jun 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. 2025 Jun 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. PMID: 30000947 Free Books & Documents. Review.
  • Aspirin.
    [No authors listed] [No authors listed] 2025 Jun 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. 2025 Jun 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. PMID: 30000255 Free Books & Documents. Review.
  • Antiretrovirals for reducing the risk of mother-to-child transmission of HIV infection.
    Siegfried N, van der Merwe L, Brocklehurst P, Sint TT. Siegfried N, et al. Cochrane Database Syst Rev. 2011 Jul 6;(7):CD003510. doi: 10.1002/14651858.CD003510.pub3. Cochrane Database Syst Rev. 2011. PMID: 21735394
  • Antiretrovirals for reducing the risk of mother-to-child transmission of HIV infection.
    Volmink J, Siegfried NL, van der Merwe L, Brocklehurst P. Volmink J, et al. Cochrane Database Syst Rev. 2007 Jan 24;(1):CD003510. doi: 10.1002/14651858.CD003510.pub2. Cochrane Database Syst Rev. 2007. Update in: Cochrane Database Syst Rev. 2011 Jul 06;(7):CD003510. doi: 10.1002/14651858.CD003510.pub3. PMID: 17253490 Updated.
  • Alcohol.
    [No authors listed] [No authors listed] 2025 Jun 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. 2025 Jun 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. PMID: 30000529 Free Books & Documents. Review.
See all similar articles

References

    1. Levy G. Salicylate pharmacokinetics in the human neonate. In: Morselli P, Garattini S, Sereni F, eds. Basic and therapeutic aspects of perinatal pharmacology. New York: Raven Press; 1975:319–30.
    1. Pütter J, Satravaha P, Stockhausen H. Quantitative analysis of the main metabolites of acetylsalicylic acid. Comparative analysis in the blood and milk of lactating women. Z Geburtshilfe Perinatol 1974;178:135–8. - PubMed
    1. Jamali F, Keshavarz E. Salicylate excretion in breast milk. Int J Pharm 1981;8:285–90. doi: 10.1016/0378-5173(81)90068-5 - DOI
    1. Findlay JW, DeAngelis RL, Kearney MF, et al. Analgesic drugs in breast milk and plasma. Clin Pharmacol Ther 1981;29:625–33. - PubMed
    1. Bailey DN, Welbert RT, Naylor A. A study of salicylate and caffeine excretion in the breast milk of two nursing mothers. J Anal Toxicol 1982;6:64–8. - PubMed

LinkOut - more resources