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Comment
. 2018 Jul 11;24(1):8-9.
doi: 10.1016/j.chom.2018.06.010.

Lipid Peroxidation Adds Fuel to Pyr(optosis)

Ashley J Russo  1 , Vijay A K Rathinam  2
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Lipid Peroxidation Adds Fuel to Pyr(optosis)

Ashley J Russo et al. Cell Host Microbe. .
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Abstract

Glutathione peroxidase 4 (GPX4) is an antioxidant enzyme that protects cells from lipid peroxidation. In this issue of Cell Host & Microbe, Kang et al. (2018) report that GPX4 is a negative regulator of the pyroptotic cell death pathway and plays an important role in inhibiting lethal inflammation associated with sepsis.

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