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Review
. 2018 Jul 12;19(7):2031.
doi: 10.3390/ijms19072031.

New Insights in Anti-Angiogenesis in Multiple Myeloma

Domenico Ribatti  1 , Angelo Vacca  2
Affiliations
Review

New Insights in Anti-Angiogenesis in Multiple Myeloma

Domenico Ribatti et al. Int J Mol Sci. .

Abstract

Angiogenesis is a constant hallmark of multiple myeloma (MM) progression and involves direct production of angiogenic cytokines by plasma cells and their induction within the bone marrow microenvironment. This article summarizes the more recent literature data concerning the employment of anti-angiogenic therapeutic agents actually used in preclinical models and clinical settings for the treatment of multiple myeloma.

Keywords: angiogenesis; anti-angiogenesis; multiple myeloma; tumor growth.

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Conflict of interest statement

There are no conflicts of interest.

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