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. 2018 Jul 12;23(7):1705.
doi: 10.3390/molecules23071705.

Hepatoprotective Principles and Other Chemical Constituents from the Mycelium of Phellinus linteus

Shiow-Chyn Huang  1 , Pei-Wen Wang  2 , Ping-Chung Kuo  3 , Hsin-Yi Hung  4 , Tai-Long Pan  5
Affiliations

Hepatoprotective Principles and Other Chemical Constituents from the Mycelium of Phellinus linteus

Shiow-Chyn Huang et al. Molecules. .

Abstract

In the dimethylnitrosamine (DMN)-induced hepatic fibrosis Wistar rat model, the mycelium extract of Phellinus linteus (PLE) (20 mg/Kg) displayed significant protection against hepatic fibrosis. The present investigation characterized eleven new ionone derivatives, phellinulins D⁻N (4⁻14), from the P. linteus mycelium extract and the relative stereochemical structures were constructed according to the spectroscopic and spectrometric analytical results. Some purified compounds were examined for their inhibitory effects on activated rat hepatic stellate cells (HSCs) and several isolates did exhibit significant protection. The results indicated that the mycelium of P. linteus could be explored as a hepatoprotective drug or healthy food candidate in the near future.

Keywords: Phellinus linteus; hepatic fibrosis; hepatic stellate cell; ionone derivative; spectroscopic and spectrometric analysis.

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Conflict of interest statement

The authors declare no conflict of interest. The founding sponsors had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript and in the decision to publish the results.

Figures

Figure 1
Figure 1
Histological changes in rat liver tissues of PLE.
Figure 2
Figure 2
Structures of compounds 1–14.
Figure 3
Figure 3
HMBC and NOESY correlations of compound 4.
Figure 4
Figure 4
HMBC and NOESY correlations of compound 5.
See this image and copyright information in PMC

References

    1. Engler M., Anke T., Sterner O. Production of antibiotics by Collybia nivalis, Omphalotus olearis, a Favolaschia and a Pterula species on natural substrates. Z. Naturforsch C. 1998;53:318–324. - PubMed
    1. Nicoletti R., Ciavatta M.L., Buommino E., Tufano M.A. Antitumor extrolites produced by Penicillium species. Int. J. Biomed. Pharm. Sci. 2008;2:1–23.
    1. Tolbert J.A. Lovastatin and beyond: The history of the HMG-CoA reductase inhibitors. Nat. Rev. Drug Discov. 2003;2:517–526. doi: 10.1038/nrd1112. - DOI - PubMed
    1. Ng T.B., Wang H.X. Pharmacological actions of Cordyceps, a prized folk medicine. J. Pharm. Pharmacol. 2005;57:1509–1520. doi: 10.1211/jpp.57.12.0001. - DOI - PubMed
    1. Han J.Y., Im J., Choi J.N., Lee C.H., Park H.J., Park D.K., Yun C.H., Han S.H. Induction of IL-8 expression by Cordyceps militaris grown on germinated soybeans through lipid rafts formation and signaling pathways via ERK and JNK in A549 cells. J. Ethnopharmacol. 2010;127:55–61. doi: 10.1016/j.jep.2009.09.051. - DOI - PubMed

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