Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Jun 28:9:1480.
doi: 10.3389/fimmu.2018.01480. eCollection 2018.

Hepatitis C Vaccines, Antibodies, and T Cells

Naglaa H Shoukry  1   2
Affiliations
Review

Hepatitis C Vaccines, Antibodies, and T Cells

Naglaa H Shoukry. Front Immunol. .

Abstract

The development of vaccines that protect against persistent hepatitis C virus (HCV) infection remain a public health priority. The broad use of highly effective direct-acting antivirals (DAAs) is unlikely to achieve HCV elimination without vaccines that can limit viral transmission. Two vaccines targeting either the antibody or the T cell response are currently in preclinical or clinical trials. Next-generation vaccines will likely involve a combination of these two strategies. This review summarizes the state of knowledge about the immune protective role of HCV-specific antibodies and T cells and the current vaccine strategies. In addition, it discusses the potential efficacy of vaccination in DAA-cured individuals. Finally, it summarizes the challenges to vaccine development and the collaborative efforts required to overcome them.

Keywords: T cells; antibodies; hepatitis C; reinfection; vaccines.

PubMed Disclaimer

References

    1. Pawlotsky JM, Feld JJ, Zeuzem S, Hoofnagle JH. From non-A, non-B hepatitis to hepatitis C virus cure. J Hepatol (2015) 62:S87–99.10.1016/j.jhep.2015.02.006 - DOI - PubMed
    1. Falade-Nwulia O, Suarez-Cuervo C, Nelson DR, Fried MW, Segal JB, Sulkowski MS. Oral direct-acting agent therapy for hepatitis C virus infection: a systematic review. Ann Intern Med (2017) 166:637–48.10.7326/M16-2575 - DOI - PMC - PubMed
    1. WHO. Global Hepatitis Report, 2017. Geneva, Switzerland: WHO; (2017).
    1. Rice CM, Saeed M. Hepatitis C: treatment triumphs. Nature (2014) 510:43–4.10.1038/510043a - DOI - PubMed
    1. Gravitz L. Introduction: a smouldering public-health crisis. Nature (2011) 474:S2.10.1038/474S2a - DOI - PubMed

LinkOut - more resources