Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Jul 1;10(1):e2018040.
doi: 10.4084/MJHID.2018.040. eCollection 2018.

Disseminated Histoplasmosis as AIDS-presentation. Case Report and Comprehensive Review of Current Literature

Paola Zanotti  1 , Claudia Chirico  1 , Maurizio Gulletta  1 , Laura Ardighieri  2 , Salvatore Casari  3 , Eugenia Quiros Roldan  1 , Ilaria Izzo  1 , Gabriele Pinsi  4 , Giovanni Lorenzin  4   5 , Fabio Facchetti  2 , Francesco Castelli  1 , Emanuele Focà  1
Affiliations
Review

Disseminated Histoplasmosis as AIDS-presentation. Case Report and Comprehensive Review of Current Literature

Paola Zanotti et al. Mediterr J Hematol Infect Dis. .

Abstract

Progressive disseminated histoplasmosis (PDH) is an AIDS-defining illness with a high lethality rate if not promptly treated. The wide range of its possible clinical manifestations represents the main barrier to diagnosis in non-endemic countries. Here we present a case of PDH with haemophagocytic syndrome in a newly diagnosed HIV patient and a comprehensive review of disseminated histoplasmosis focused on epidemiology, clinical features, diagnostic tools and treatment options in HIV-infected patients.

Keywords: AIDS; Disseminated histoplasmosis; HIV; Histoplasma capsulatum.

PubMed Disclaimer

Conflict of interest statement

Competing interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1
Representative section of the tonsil showing a prominent sub-epithelial histiocytic infiltrate (hematoxylin and eosin staining, 100X).
Figure 2
Figure 2
Tonsil. Cytomorphological details, showing foamy histiocytes containing intracytoplasmic yeasts(hematoxylin and eosin staining, 600X).
Figure 3
Figure 3
Tonsil. Grocott’s methenamine silver (GMS) stain highlighting intracytoplasmatic fungal elements. (GMS staining, 600X).
See this image and copyright information in PMC

References

    1. Köhler JR, Hube B, Puccia R, Casadevall A, Perfect JR. Fungi that Infect Humans. Microbiol Spectr. 2017 Jun;5(3) doi: 10.1128/microbiolspec.FUNK-0014-2016. - DOI - PMC - PubMed
    1. Subedee A, Van Sickels N. Hemophagocytic Syndrome in the Setting of AIDS and Disseminated Histoplasmosis: Case Report and a Review of Literature. J Int Assoc Provid AIDS Care. 2015 Sep-Oct;14(5):391–7. doi: 10.1177/2325957415570740. - DOI - PubMed
    1. Horwath MC, Fecher RA, Deepe GS., Jr Histoplasma capsulatum, lung infection and immunity. Future Microbiol. 2015;10(6):967–75. doi: 10.2217/fmb.15.25. - DOI - PMC - PubMed
    1. Jones JL, Hanson DL, Dworkin MS, Alderton DL, Fleming PL, Kaplan JE, Ward J. Surveillance for AIDS-defining opportunistic illnesses, 1992–1997. MMWR CDC Surveill Summ. 1999 Apr 16;48(2):1–22. doi: 10.1001/archderm.135.8.897. - DOI - PubMed
    1. Martin-Iguacel R, Kurtzhals J, Jouvion G, Nielsen SD, Llibre JM. Progressive disseminated histoplasmosis in the HIV population in Europe in the HAART era. Case report and literature review. Infection. 2014 Aug;42(4):611–20. doi: 10.1007/s15010-014-0611-7. - DOI - PubMed