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. 2018 Apr;2(2):pky024.
doi: 10.1093/jncics/pky024. Epub 2018 Jun 28.

Comparing Survival After Recurrent vs De Novo Stage IV Advanced Breast, Lung, and Colorectal Cancer

Michael J Hassett  1   2 , Hajime Uno  1   2 , Angel M Cronin  1 , Nikki M Carroll  3 , Mark C Hornbrook  4 , Debra P Ritzwoller  3
Affiliations

Comparing Survival After Recurrent vs De Novo Stage IV Advanced Breast, Lung, and Colorectal Cancer

Michael J Hassett et al. JNCI Cancer Spectr. 2018 Apr.

Abstract

The treatments provided to and survival of patients with recurrent vs de novo stage IV advanced breast, lung, and colorectal cancer may differ but have not been well studied. Using population-based data from the Cancer Research Network for 4510 patients with advanced breast, lung, or colorectal cancer, we matched recurrent/de novo patients on demographic factors. We found longer survival for recurrent vs de novo lung cancer (182 matched pairs); no significant difference for colorectal cancer (332 matched pairs); and shorter survival for recurrent vs de novo breast cancer (219 matched pairs). Compared with recurrent cases, chemotherapy use and radiation therapy use were more common among de novo cases. Differences in treatment and survival between recurrent and de novo advanced cancer patients could inform prognostic estimates and clinical trial design.

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Figures

Figure 1.
Figure 1.
Kaplan-Meier plot of overall survival following a diagnosis of recurrent vs de novo stage IV metastatic cancer (propensity score–matched sample). Propensity score was matched on age, sex, race, marital status, smoking status, income, comorbidity score, and diagnosis year.
See this image and copyright information in PMC

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References

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