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. 2019 Feb;23(1):75-84.
doi: 10.1007/s11030-018-9847-y. Epub 2018 Jul 12.

A facile solvent-free three-component domino synthesis of novel 2,4-diaryl-5,6-dihydrobenzo[j][1,7]phenanthrolines

Shanmugavel Uma Maheswari  1   2 , Sundaravel Vivek Kumar  1 , Shanmugam Muthusubramanian  3 , Subbu Perumal  1
Affiliations

A facile solvent-free three-component domino synthesis of novel 2,4-diaryl-5,6-dihydrobenzo[j][1,7]phenanthrolines

Shanmugavel Uma Maheswari et al. Mol Divers. 2019 Feb.

Abstract

A simple, efficient and green procedure for the synthesis of novel 2,4-diaryl-5,6-dihydrobenzo[j][1,7]phenanthrolines has been developed via a Krohnke-type one-pot three-component reaction of 2-[arylmethylidene]-3,4-dihydro-1(2H)-acridinones and (2-aryl-2-oxoethyl)pyridinium bromides in the presence of excess ammonium acetate in good yields under solvent-free conditions. Good functional group tolerance, high substrate scope and no column purification are the practical advantages of this methodology.

Keywords: Dihydrobenzo[j][1,7]phenanthrolines; Green chemistry; MCRs; Multicomponent domino reaction; Solvent-free reaction.

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