Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Feb;23(1):75-84.
doi: 10.1007/s11030-018-9847-y. Epub 2018 Jul 12.

A facile solvent-free three-component domino synthesis of novel 2,4-diaryl-5,6-dihydrobenzo[j][1,7]phenanthrolines

Shanmugavel Uma Maheswari  1   2 , Sundaravel Vivek Kumar  1 , Shanmugam Muthusubramanian  3 , Subbu Perumal  1
Affiliations

A facile solvent-free three-component domino synthesis of novel 2,4-diaryl-5,6-dihydrobenzo[j][1,7]phenanthrolines

Shanmugavel Uma Maheswari et al. Mol Divers. 2019 Feb.

Abstract

A simple, efficient and green procedure for the synthesis of novel 2,4-diaryl-5,6-dihydrobenzo[j][1,7]phenanthrolines has been developed via a Krohnke-type one-pot three-component reaction of 2-[arylmethylidene]-3,4-dihydro-1(2H)-acridinones and (2-aryl-2-oxoethyl)pyridinium bromides in the presence of excess ammonium acetate in good yields under solvent-free conditions. Good functional group tolerance, high substrate scope and no column purification are the practical advantages of this methodology.

Keywords: Dihydrobenzo[j][1,7]phenanthrolines; Green chemistry; MCRs; Multicomponent domino reaction; Solvent-free reaction.

PubMed Disclaimer

References

    1. Chem Rev. 2012 Jun 13;112(6):3083-135 - PubMed
    1. Mini Rev Med Chem. 2009 Dec;9(14):1648-54 - PubMed
    1. Chem Rev. 2000 Mar 8;100(3):1025-74 - PubMed
    1. Med Res Rev. 2000 Jul;20(4):304-22 - PubMed
    1. Chem Rev. 1996 Feb 1;96(1):115-136 - PubMed

MeSH terms

Substances

LinkOut - more resources