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. 2018 Sep;34(9):790-793.
doi: 10.1089/AID.2018.0114. Epub 2018 Aug 22.

Short Communication: Protective Efficacy of Broadly Neutralizing Antibody PGDM1400 Against HIV-1 Challenge in Humanized Mice

Yme U van der Velden  1 , Julien Villaudy  1   2 , Esther Siteur-van Rijnstra  3 , Cynthia A van der Linden  1   3 , Esmay Frankin  1 , Kees Weijer  3 , Edith Schermer  1 , Monique A Vink  1 , Ben Berkhout  1 , Rogier W Sanders  1   4 , Marit J van Gils  1
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Short Communication: Protective Efficacy of Broadly Neutralizing Antibody PGDM1400 Against HIV-1 Challenge in Humanized Mice

Yme U van der Velden et al. AIDS Res Hum Retroviruses. 2018 Sep.

Abstract

Broadly neutralizing antibodies (bNAbs) such as PGDM1400 show promise as prophylactic and therapeutic agents against HIV-1. Human immune system mice were passively immunized with different doses of PGDM1400 and challenged 24 h later with a high dose of HIV-1JRCSF. We found that PGDM1400 provided protection against HIV-1 challenge in a concentration dependent manner and that the protective concentration in blood was ∼75-fold higher than the in vitro 50% inhibitory concentration. The results demonstrate that PGDM1400 might be a promising component of strategies to prevent HIV-1 infection and provide support for the pursuit of vaccines that induce PGDM1400-like bNAbs.

Keywords: HIV-1; PGDM1400; broadly neutralizing antibody; human immune system mouse; prophylactic agent.

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