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Review
. 2019 Jan;92(1093):20180188.
doi: 10.1259/bjr.20180188. Epub 2018 Jul 30.

Cancer immunology and radiobiology: Oliver Scott's struggle for the perfect tumour model in translational research

Klaus-Rüdiger Trott  1
Affiliations
Review

Cancer immunology and radiobiology: Oliver Scott's struggle for the perfect tumour model in translational research

Klaus-Rüdiger Trott. Br J Radiol. 2019 Jan.

Abstract

Oliver Scott is best known for his research into the role of tumour hypoxia in radiation oncology. Yet no less important were Oliver's activities in the development of concepts and methods for performing translational research on the effect of ionising radiation on tumour in experimental animals, stressing the importance of using strictly inbred animals for transplantation of tumours which had arisen in exactly the identical mouse strain. Otherwise residual immunity would lead to uncontrollable bias in the results of cure experiments, invalidating conclusions. These pioneering views are no less valid in today's cancer research.

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References

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