Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2019 Jan 1;12(1):22-24.
doi: 10.1213/XAA.0000000000000834.

Profound Bradycardia and Cardiac Arrest After Sugammadex Administration in a Previously Healthy Patient: A Case Report

Affiliations
Case Reports

Profound Bradycardia and Cardiac Arrest After Sugammadex Administration in a Previously Healthy Patient: A Case Report

Ivanna A Sanoja et al. A A Pract. .

Abstract

We report the case of a 60-year-old man who underwent open radical prostatectomy for prostate adenocarcinoma. He had no known cardiac disease or symptoms other than controlled hypertension and remote history of cocaine use. The patient was given sugammadex for reversal of neuromuscular blockade and, within 1 minute, developed severe, drug-resistant bradycardia followed by pulseless electrical activity arrest. Advanced cardiac life support was initiated and continued for 15 minutes before the return of spontaneous circulation. Subsequent cardiac workup showed no abnormalities. We believe the cause of arrest was sugammadex, considering the time of administration, the absence of cardiac disease, and stable operative course.

PubMed Disclaimer

References

    1. Naguib MSugammadex: another milestone in clinical neuromuscular pharmacology. Anesth Analg. 2007;104:575581.
    1. Welliver M, McDonough J, Kalynych N, Redfern RDiscovery, development, and clinical application of sugammadex sodium, a selective relaxant binding agent. Drug Des Devel Ther. 2009;2:4959.
    1. Tsur A, Kalansky AHypersensitivity associated with sugammadex administration: a systematic review. Anaesthesia. 2014;69:12511257.
    1. Saito I, Osaka Y, Shimada MTransient third-degree AV block following sugammadex. J Anesth. 2015;29:641.
    1. Bilgi M, Demirhan A, Akkaya A, Tekelioglu UY, Kocoglu HSugammadex associated persistent bradycardia. Int J Med Sci Public Health. 2014;3:372374.

Publication types

LinkOut - more resources