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Multicenter Study
. 2018 Dec;14(12):1565-1571.
doi: 10.1016/j.jalz.2018.06.1353. Epub 2018 Jul 11.

Standardization of amyloid quantitation with florbetapir standardized uptake value ratios to the Centiloid scale

Michael Navitsky  1 , Abhinay D Joshi  1 , Ian Kennedy  1 , William E Klunk  2 , Christopher C Rowe  3 , Dean F Wong  4 , Michael J Pontecorvo  1 , Mark A Mintun  1 , Michael D Devous Sr  5
Affiliations
Multicenter Study

Standardization of amyloid quantitation with florbetapir standardized uptake value ratios to the Centiloid scale

Michael Navitsky et al. Alzheimers Dement. 2018 Dec.

Abstract

Introduction: Klunk et al. recently proposed a means of standardizing quantitation of amyloid burden from positron emission tomography scans to a common Centiloid scale, and we have applied that method to florbetapir.

Methods: Florbetapir and Pittsburgh compound B scans were acquired for 46 mixed clinical presentation subjects within 18 ± 20 days. Florbetapir and Pittsburgh compound B cortical standardized uptake value ratio (SUVr) values were well correlated for both standard Centiloid (R2 = 0.894) and Avid (R2 = 0.901) volume of interests (VOIs). The methods of Klunk et al. were applied to establish a conversion first from florbetapir SUVr values obtained using standard Centiloid VOIs to Centiloids and then from Avid VOIs (Joshi et al.) to Centiloids.

Results: The equation for conversion of florbetapir SUVr from Avid VOIs to the Centiloid scale was as follows: Florbetapir Centiloids = 183 × SUVrAvid - 177. The threshold that discriminated neuropathologically verified none or sparse versus moderate to frequent plaques in autopsy-confirmed data is 24.1 Centiloids.

Discussion: These findings may allow improved tracer-independent amyloid quantitation.

Keywords: Amyloid imaging; Centiloids; Florbetapir; Pittsburgh compound B; Standardization.

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