Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2018 Oct:368:1-2.
doi: 10.1016/j.heares.2018.06.018. Epub 2018 Jun 28.

Local drug delivery to the inner ear: Principles, practice, and future challenges

Stefan K Plontke  1 , Alec N Salt  2
Affiliations
Editorial

Local drug delivery to the inner ear: Principles, practice, and future challenges

Stefan K Plontke et al. Hear Res. 2018 Oct.
No abstract available

PubMed Disclaimer

Figures

Figure 1:
Figure 1:
Number of publications per year during a 25-year period as a result of a search in PubMed Central on the search terms “Drug Delivery Inner Ear” and “Intratympanic Drug”. Although changes in search terms will lead to slight changes in absolute numbers in the histogram, a rapid growth in publications per year is apparent since the mid 1990’s, when local gentamicin therapy, pioneered by Lange (1989), became widely-adopted as an effective therapy for Meniere’s disease.
See this image and copyright information in PMC

References

    1. Canlon B 2018. Circadian regulation of the inner ear, lecture notes, Barany Society Meeting, delivered June 11th, 2018
    1. Chen W, Jongkamonwiwat N, Abbas L, Eshtan SJ, Johnson SL, Kuhn S, Milo M, Thurlow JK, Andrews PW, Marcotti W, Moore HD, Rivolta MN. Restoration of auditory evoked responses by human ES-cell-derived otic progenitors. Nature. 2012. October 11;490(7419):278–82. - PMC - PubMed
    1. da Cruz L, Fynes K, Georgiadis O, Kerby J, Luo YH, Ahmado A, Vernon A, Daniels JT, Nommiste B, Hasan SM, Gooljar SB, Carr AF, Vugler A, Ramsden CM, Bictash M, Fenster M, Steer J, Harbinson T, Wilbrey A, Tufail A, Feng G, Whitlock M, Robson AG, Holder GE, Sagoo MS, Loudon PT, Whiting P, Coffey PJ. Phase 1 clinical study of an embryonic stem cell-derived retinal pigment epithelium patch in age-related macular degeneration. Nat Biotechnol. 2018. March 19. - PubMed
    1. Lange G: Gentamicin and other ototoxic antibiotics for the transtympanic treatment of Menière’s disease. Arch Otorhinolaryngol 1989; 246: 269–270. - PubMed
    1. Livingston G, Sommerlad A, Orgeta V, Costafreda SG, Huntley J, Ames D, Ballard C, Banerjee S, Burns A, Cohen-Mansfield J, Cooper C, Fox N, Gitlin LN, Howard R, Kales HC, Larson EB, Ritchie K, Rockwood K, Sampson EL, Samus Q, Schneider LS, Selbæk G, Teri L, Mukadam N. Dementia prevention, intervention, and care. Lancet. 2017. December 16;390(10113):2673–2734. - PubMed

Publication types

MeSH terms

Substances