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Comment
. 2018 Sep;8(9):1055.
doi: 10.1158/2159-8290.CD-NB2018-093. Epub 2018 Jul 13.

CDK12 Changes Telling in Prostate Cancer

No authors listed
Comment

CDK12 Changes Telling in Prostate Cancer

No authors listed. Cancer Discov. 2018 Sep.

Abstract

A recent study established that patients with metastatic castration-resistant prostate cancer who had mutations that inactivated both CDK12 alleles also exhibited other genetic changes. Results of a small, related study suggest these genetic changes may make tumors more responsive to PD-1 inhibitors.

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  • Inactivation of CDK12 Delineates a Distinct Immunogenic Class of Advanced Prostate Cancer.
    Wu YM, Cieślik M, Lonigro RJ, Vats P, Reimers MA, Cao X, Ning Y, Wang L, Kunju LP, de Sarkar N, Heath EI, Chou J, Feng FY, Nelson PS, de Bono JS, Zou W, Montgomery B, Alva A; PCF/SU2C International Prostate Cancer Dream Team; Robinson DR, Chinnaiyan AM. Wu YM, et al. Cell. 2018 Jun 14;173(7):1770-1782.e14. doi: 10.1016/j.cell.2018.04.034. Cell. 2018. PMID: 29906450 Free PMC article.

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