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. 2018 Jul 12;174(2):251-253.
doi: 10.1016/j.cell.2018.06.037.

The Tuft Cell-ILC2 Circuit Integrates Intestinal Defense and Homeostasis

Yoku Hayakawa  1 , Timothy C Wang  2
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The Tuft Cell-ILC2 Circuit Integrates Intestinal Defense and Homeostasis

Yoku Hayakawa et al. Cell. .
Free article

Abstract

The intestinal response to helminth infection is mediated by a recently established type 2 immune circuit that consists of intestinal tuft cells and type 2 innate lymphoid cells (ILC2s). Schneider et al. have discovered that tuft cells sense succinate fermented by Tritrichomonas via GPR91 to drive the IL-25-ILC2-IL-13-dependent immune circuit and intestinal remodeling.

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