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Review
. 2018 Aug;38(3):469-481.
doi: 10.1016/j.iac.2018.04.002. Epub 2018 Jun 9.

Nonclonal Mast Cell Activation Syndrome: A Growing Body of Evidence

Matthew J Hamilton  1
Affiliations
Review

Nonclonal Mast Cell Activation Syndrome: A Growing Body of Evidence

Matthew J Hamilton. Immunol Allergy Clin North Am. 2018 Aug.

Abstract

Patients who present with typical features of mast cell activation with laboratory confirmation and without evidence of a clonal mast cell disorder or other medical condition should be initiated on medical treatment to block mast cells and their mediators. If a major response is achieved, a diagnosis of nonclonal mast cell activation syndrome (NC-MCAS) is likely and treatment should be optimized, including management of any associated conditions. In this review, the latest evidence with regard to the diagnosis and treatment of NC-MCAS is presented.

Keywords: Flushing; Histamine; Mast cell; Mast cell activation syndrome; Mastocytosis; Prostaglandin; Tryptase.

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Figures

Figure 1
Figure 1
Classification Schemes of Mast Cell Activation Disorders.
See this image and copyright information in PMC

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